Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A
Background and Objective: Bisphenol A (BPA) is the monometer of epoxy resins and polycarbonate plastics that plays an important role in the pathogenesis of cardiovascular diseases. This study was done to evaluate the effect of aerobic exercises on oxidative stress indices in heart tissue of male Wis...
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2021-01-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/article-1-3726-en.html |
| _version_ | 1818871862949576704 |
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| author | Farhad Pashazadeh Asghar Tofighi Siyamak Asri Rezaei Javad Tolouei Azar |
| author_facet | Farhad Pashazadeh Asghar Tofighi Siyamak Asri Rezaei Javad Tolouei Azar |
| author_sort | Farhad Pashazadeh |
| collection | DOAJ |
| description | Background and Objective: Bisphenol A (BPA) is the monometer of epoxy resins and polycarbonate plastics that plays an important role in the pathogenesis of cardiovascular diseases. This study was done to evaluate the effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A.
Methods: In this experimental study, 20 adult male Wistar rats were allocated into four groups including control, aerobic exercise, BPA and BPA + aerobic exercise. Animals in control and aerobic exercise groups were receieved olive oil and the BPA (100 μg/kg) intraperitoneally, respectively. Animals in BPA + aerobic training group were treated with BPA (100 μg/kg) intraperitoneally for 30 days. Exercise program consisted of 25-64 minutes of running with 57-75% oxygen consumption, 5 sessions per week for two months. Indicators of oxidative stress in heart tissue including Gpx, SOD, TAC, MDA, CAT and AOPP were evaluated.
Results: BPA intoxication induced a significant increase in the activity of SOD , GPX enzymes, AOPP and MDA levels and reduction in CAT enzyme activity and TAC level in compared to control group (P<0.05). While aerobic exercise could diminish the oxidative stress due to BPA intoxication. Aerobic exercise reduced the activity of the GPX, SOD and increased catalase activity in rats with BPA intoxication (P<0.05). Also, level of MDA and AOPP significantly reduced in in aerobic exercise group in comparison with with BPA intoxication (P<0.05).
Conclusion: Aerobic exercise activity has moderating effects on BPA intoxication in cardiac oxidative stress. Aerobic exercise can increase the amount of antioxidant enzymes that play an important role in modulating oxidative stress induced by BPA. |
| first_indexed | 2024-12-19T12:29:40Z |
| format | Article |
| id | doaj.art-99efede473a64409a0bc8f823c45c4ed |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-19T12:29:40Z |
| publishDate | 2021-01-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-99efede473a64409a0bc8f823c45c4ed2022-12-21T20:21:26ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802021-01-012245462Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol AFarhad Pashazadeh0Asghar Tofighi1Siyamak Asri Rezaei2Javad Tolouei Azar3 Ph.D Candidate in Exercise Physiology, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran. Associate Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran. Associate Professor, Department of Internal Diseases and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Assistant Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran. Background and Objective: Bisphenol A (BPA) is the monometer of epoxy resins and polycarbonate plastics that plays an important role in the pathogenesis of cardiovascular diseases. This study was done to evaluate the effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A. Methods: In this experimental study, 20 adult male Wistar rats were allocated into four groups including control, aerobic exercise, BPA and BPA + aerobic exercise. Animals in control and aerobic exercise groups were receieved olive oil and the BPA (100 μg/kg) intraperitoneally, respectively. Animals in BPA + aerobic training group were treated with BPA (100 μg/kg) intraperitoneally for 30 days. Exercise program consisted of 25-64 minutes of running with 57-75% oxygen consumption, 5 sessions per week for two months. Indicators of oxidative stress in heart tissue including Gpx, SOD, TAC, MDA, CAT and AOPP were evaluated. Results: BPA intoxication induced a significant increase in the activity of SOD , GPX enzymes, AOPP and MDA levels and reduction in CAT enzyme activity and TAC level in compared to control group (P<0.05). While aerobic exercise could diminish the oxidative stress due to BPA intoxication. Aerobic exercise reduced the activity of the GPX, SOD and increased catalase activity in rats with BPA intoxication (P<0.05). Also, level of MDA and AOPP significantly reduced in in aerobic exercise group in comparison with with BPA intoxication (P<0.05). Conclusion: Aerobic exercise activity has moderating effects on BPA intoxication in cardiac oxidative stress. Aerobic exercise can increase the amount of antioxidant enzymes that play an important role in modulating oxidative stress induced by BPA.http://goums.ac.ir/journal/article-1-3726-en.htmlbisphenol aexerciseoxidative stressheart |
| spellingShingle | Farhad Pashazadeh Asghar Tofighi Siyamak Asri Rezaei Javad Tolouei Azar Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A مجله دانشگاه علوم پزشکی گرگان bisphenol a exercise oxidative stress heart |
| title | Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A |
| title_full | Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A |
| title_fullStr | Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A |
| title_full_unstemmed | Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A |
| title_short | Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A |
| title_sort | effect of aerobic exercises on oxidative stress indices in heart tissue of male wistar rats after poisoning with bisphenol a |
| topic | bisphenol a exercise oxidative stress heart |
| url | http://goums.ac.ir/journal/article-1-3726-en.html |
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