Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight
Our study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6.3, BMI 31 ± 4 kg/m<sup>2</sup>), and...
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/12/2694 |
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| author | Jan Budzianowski Jarosław Hiczkiewicz Katarzyna Łojewska Edyta Kawka Rafał Rutkowski Katarzyna Korybalska |
| author_facet | Jan Budzianowski Jarosław Hiczkiewicz Katarzyna Łojewska Edyta Kawka Rafał Rutkowski Katarzyna Korybalska |
| author_sort | Jan Budzianowski |
| collection | DOAJ |
| description | Our study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6.3, BMI 31 ± 4 kg/m<sup>2</sup>), and 60 men (age: 60.7 ± 6.7; BMI 31 ± 3 kg/m<sup>2</sup>) with paroxysmal, persistent and long-standing persistent AF. They had been scheduled to undergo cryoballoon (men <i>n</i> = 30; women <i>n</i> = 30) and radiofrequency (RF) ablation (men <i>n</i> = 30; women <i>n</i> = 24) using the CARTO-mapping. The blood was collected at baseline and 24 h after ablation. The rate of ERAF was comparable after cryoballoon and RF ablation and constituted 18% in women and 22% in men. Almost 70 parameters were selected to perform univariate and multivariate analysis and to create a multivariate logistic regression (MLR) model of ERAF in the obese men and women. The MLR analysis was performed by forward stepwise logistic regression with three variables. It was only possible to create the MLR model for the group of obese men. It revealed a poor predictive value with an unsatisfactory sensitivity of 31%. Men with ERAF: smokers (OR 39.25, 95% CI 1.050–1467.8, <i>p</i> = 0.0021), with a higher ST2 elevation (OR 1.68, 95% CI 1.115–2.536, <i>p</i> = 0.0021) who received dihydropyridine calcium channel blockers (OR 0.042, 95% CI 0.002–1.071, <i>p</i> = 0.0021) less frequently. Our results indicate a complex pathogenesis of ERAF dependent on the patients’ gender. |
| first_indexed | 2024-03-10T10:17:45Z |
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| id | doaj.art-99f034255234440ca1adf06f553f44ec |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:17:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-99f034255234440ca1adf06f553f44ec2023-11-22T00:44:05ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011012269410.3390/jcm10122694Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body WeightJan Budzianowski0Jarosław Hiczkiewicz1Katarzyna Łojewska2Edyta Kawka3Rafał Rutkowski4Katarzyna Korybalska5Department of Cardiology, Nowa Sól Multidisciplinary Hospital, 67-100 Nowa Sól, PolandDepartment of Cardiology, Nowa Sól Multidisciplinary Hospital, 67-100 Nowa Sól, PolandDepartment of Cardiology, Nowa Sól Multidisciplinary Hospital, 67-100 Nowa Sól, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandOur study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6.3, BMI 31 ± 4 kg/m<sup>2</sup>), and 60 men (age: 60.7 ± 6.7; BMI 31 ± 3 kg/m<sup>2</sup>) with paroxysmal, persistent and long-standing persistent AF. They had been scheduled to undergo cryoballoon (men <i>n</i> = 30; women <i>n</i> = 30) and radiofrequency (RF) ablation (men <i>n</i> = 30; women <i>n</i> = 24) using the CARTO-mapping. The blood was collected at baseline and 24 h after ablation. The rate of ERAF was comparable after cryoballoon and RF ablation and constituted 18% in women and 22% in men. Almost 70 parameters were selected to perform univariate and multivariate analysis and to create a multivariate logistic regression (MLR) model of ERAF in the obese men and women. The MLR analysis was performed by forward stepwise logistic regression with three variables. It was only possible to create the MLR model for the group of obese men. It revealed a poor predictive value with an unsatisfactory sensitivity of 31%. Men with ERAF: smokers (OR 39.25, 95% CI 1.050–1467.8, <i>p</i> = 0.0021), with a higher ST2 elevation (OR 1.68, 95% CI 1.115–2.536, <i>p</i> = 0.0021) who received dihydropyridine calcium channel blockers (OR 0.042, 95% CI 0.002–1.071, <i>p</i> = 0.0021) less frequently. Our results indicate a complex pathogenesis of ERAF dependent on the patients’ gender.https://www.mdpi.com/2077-0383/10/12/2694catheter ablationatrial fibrillationobesityearly recurrencebiomarkers |
| spellingShingle | Jan Budzianowski Jarosław Hiczkiewicz Katarzyna Łojewska Edyta Kawka Rafał Rutkowski Katarzyna Korybalska Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight Journal of Clinical Medicine catheter ablation atrial fibrillation obesity early recurrence biomarkers |
| title | Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight |
| title_full | Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight |
| title_fullStr | Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight |
| title_full_unstemmed | Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight |
| title_short | Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight |
| title_sort | predictors of early recurrence atrial fibrillation after catheter ablation in women and men with abnormal body weight |
| topic | catheter ablation atrial fibrillation obesity early recurrence biomarkers |
| url | https://www.mdpi.com/2077-0383/10/12/2694 |
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