Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domain...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.866444/full |
| _version_ | 1818147206970998784 |
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| author | Inés González-Calvo Mélissa Cizeron Jean-Louis Bessereau Fekrije Selimi |
| author_facet | Inés González-Calvo Mélissa Cizeron Jean-Louis Bessereau Fekrije Selimi |
| author_sort | Inés González-Calvo |
| collection | DOAJ |
| description | The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These domains are found in invertebrates and vertebrates, and CUB and CCP domains were initially described in proteins belonging to the complement system of innate immunity. Interestingly, they are found in synapses of the nematode C. elegans, which does not have a complement system, suggesting an ancient function. Comparison of the roles of CUB-, CCP-, and TSP-1 containing synaptic proteins in various species shows that in more complex nervous systems, these structural domains are combined with other domains and that there is partial conservation of their function. These three domains are thus basic building blocks of the synaptic architecture. Further studies of structural domains characteristic of synaptic proteins in invertebrates such as C. elegans and comparison of their role in mammals will help identify other conserved synaptic molecular building blocks. Furthermore, this type of functional comparison across species will also identify structural domains added during evolution in correlation with increased complexity, shedding light on mechanisms underlying cognition and brain diseases. |
| first_indexed | 2024-12-11T12:31:34Z |
| format | Article |
| id | doaj.art-99f0ee9b78e24b179e78374dd21bd21c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T12:31:34Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-99f0ee9b78e24b179e78374dd21bd21c2022-12-22T01:07:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.866444866444Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural DomainsInés González-Calvo0Mélissa Cizeron1Jean-Louis Bessereau2Fekrije Selimi3Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, FranceUniv Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5284, INSERM U-1314, MeLiS, Institut NeuroMyoGène, Lyon, FranceUniv Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5284, INSERM U-1314, MeLiS, Institut NeuroMyoGène, Lyon, FranceCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, FranceThe appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These domains are found in invertebrates and vertebrates, and CUB and CCP domains were initially described in proteins belonging to the complement system of innate immunity. Interestingly, they are found in synapses of the nematode C. elegans, which does not have a complement system, suggesting an ancient function. Comparison of the roles of CUB-, CCP-, and TSP-1 containing synaptic proteins in various species shows that in more complex nervous systems, these structural domains are combined with other domains and that there is partial conservation of their function. These three domains are thus basic building blocks of the synaptic architecture. Further studies of structural domains characteristic of synaptic proteins in invertebrates such as C. elegans and comparison of their role in mammals will help identify other conserved synaptic molecular building blocks. Furthermore, this type of functional comparison across species will also identify structural domains added during evolution in correlation with increased complexity, shedding light on mechanisms underlying cognition and brain diseases.https://www.frontiersin.org/articles/10.3389/fnins.2022.866444/fullsynapsemolecular conservationCCPCUBTSP-1invertebrates |
| spellingShingle | Inés González-Calvo Mélissa Cizeron Jean-Louis Bessereau Fekrije Selimi Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains Frontiers in Neuroscience synapse molecular conservation CCP CUB TSP-1 invertebrates |
| title | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains |
| title_full | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains |
| title_fullStr | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains |
| title_full_unstemmed | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains |
| title_short | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains |
| title_sort | synapse formation and function across species ancient roles for ccp cub and tsp 1 structural domains |
| topic | synapse molecular conservation CCP CUB TSP-1 invertebrates |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.866444/full |
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