Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats
The investigation of how to control the development and growth of cerebral aneurysms is important for the prevention of subarachnoid hemorrhage. Although there have been several types of research studies on computational fluid dynamics (CFD) analysis of brain aneurysm development and growth, there h...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Japan Neurosurgical Society
2023-06-01
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| Series: | Neurologia Medico-Chirurgica |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/nmc/63/6/63_2023-0005/_pdf/-char/en |
| _version_ | 1797785458438045696 |
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| author | Shoichi KOMURA Katsuya KOMATSU Takeshi MIKAMI Yukinori AKIYAMA Sangnyon KIM Rei ENATSU Hiroshi NAGAHAMA Nobuhiro MIKUNI |
| author_facet | Shoichi KOMURA Katsuya KOMATSU Takeshi MIKAMI Yukinori AKIYAMA Sangnyon KIM Rei ENATSU Hiroshi NAGAHAMA Nobuhiro MIKUNI |
| author_sort | Shoichi KOMURA |
| collection | DOAJ |
| description | The investigation of how to control the development and growth of cerebral aneurysms is important for the prevention of subarachnoid hemorrhage. Although there have been several types of research studies on computational fluid dynamics (CFD) analysis of brain aneurysm development and growth, there has been no unified interpretation of the CFD analysis results. The purpose of this study is to clarify the characteristics of CFD analysis results related to the development of cerebral aneurysms using an animal model. Nineteen rat models of cerebral aneurysms were created, and the CFD analysis results between the cerebral aneurysm group [n = 10; the aneurysm was observed on magnetic resonance angiography (MRA) within 10 weeks after aneurysm induction surgery] and the nonaneurysm group (n = 9) were compared. All aneurysms were confirmed on the proximal segment of the left cerebral artery (P1), and the cross-sectional area and curvature of the left P1 were evaluated together. In the cerebral aneurysm group, there was a decrease in wall shear stress (WSS) that is consistent with the location of the aneurysm compared to the nonaneurysm group. The cross-sectional area of the left P1 gradually increased in the aneurysm group but not in the nonaneurysm group. The mean curvature in the entire left P1 was higher in the aneurysm group than in the nonaneurysm group. This study revealed that the development of cerebral aneurysms is due to changes in vascular morphology, namely, an increase in vessel diameter and a high curvature, and a decreased WSS consistent with the site of aneurysm development using this animal model. |
| first_indexed | 2024-03-13T00:54:21Z |
| format | Article |
| id | doaj.art-99f1c0c0521642c6b8ec991ba21ee810 |
| institution | Directory Open Access Journal |
| issn | 1349-8029 |
| language | English |
| last_indexed | 2024-03-13T00:54:21Z |
| publishDate | 2023-06-01 |
| publisher | The Japan Neurosurgical Society |
| record_format | Article |
| series | Neurologia Medico-Chirurgica |
| spelling | doaj.art-99f1c0c0521642c6b8ec991ba21ee8102023-07-07T07:41:26ZengThe Japan Neurosurgical SocietyNeurologia Medico-Chirurgica1349-80292023-06-0163625025710.2176/jns-nmc.2023-00052023-0005Computational Fluid Dynamics Analysis Features in Aneurysm Development in RatsShoichi KOMURA0Katsuya KOMATSU1Takeshi MIKAMI2Yukinori AKIYAMA3Sangnyon KIM4Rei ENATSU5Hiroshi NAGAHAMA6Nobuhiro MIKUNI7Department of Neurosurgery, Sapporo Medical UniversityDepartment of Neurosurgery, Sapporo Medical UniversityDepartment of Neurosurgery, Sapporo Medical UniversityDepartment of Neurosurgery, Sapporo Medical UniversityDepartment of Neurosurgery, Sapporo Medical UniversityDepartment of Neurosurgery, Sapporo Medical UniversityDivision of Radioisotope Research, Biomedical Research, Education and Instrumentation Center, Sapporo Medical University School of MedicineDepartment of Neurosurgery, Sapporo Medical UniversityThe investigation of how to control the development and growth of cerebral aneurysms is important for the prevention of subarachnoid hemorrhage. Although there have been several types of research studies on computational fluid dynamics (CFD) analysis of brain aneurysm development and growth, there has been no unified interpretation of the CFD analysis results. The purpose of this study is to clarify the characteristics of CFD analysis results related to the development of cerebral aneurysms using an animal model. Nineteen rat models of cerebral aneurysms were created, and the CFD analysis results between the cerebral aneurysm group [n = 10; the aneurysm was observed on magnetic resonance angiography (MRA) within 10 weeks after aneurysm induction surgery] and the nonaneurysm group (n = 9) were compared. All aneurysms were confirmed on the proximal segment of the left cerebral artery (P1), and the cross-sectional area and curvature of the left P1 were evaluated together. In the cerebral aneurysm group, there was a decrease in wall shear stress (WSS) that is consistent with the location of the aneurysm compared to the nonaneurysm group. The cross-sectional area of the left P1 gradually increased in the aneurysm group but not in the nonaneurysm group. The mean curvature in the entire left P1 was higher in the aneurysm group than in the nonaneurysm group. This study revealed that the development of cerebral aneurysms is due to changes in vascular morphology, namely, an increase in vessel diameter and a high curvature, and a decreased WSS consistent with the site of aneurysm development using this animal model.https://www.jstage.jst.go.jp/article/nmc/63/6/63_2023-0005/_pdf/-char/enanimal aneurysm modelcomputational fluid dynamicslow wssdolichoectatic aneurysm |
| spellingShingle | Shoichi KOMURA Katsuya KOMATSU Takeshi MIKAMI Yukinori AKIYAMA Sangnyon KIM Rei ENATSU Hiroshi NAGAHAMA Nobuhiro MIKUNI Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats Neurologia Medico-Chirurgica animal aneurysm model computational fluid dynamics low wss dolichoectatic aneurysm |
| title | Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats |
| title_full | Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats |
| title_fullStr | Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats |
| title_full_unstemmed | Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats |
| title_short | Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats |
| title_sort | computational fluid dynamics analysis features in aneurysm development in rats |
| topic | animal aneurysm model computational fluid dynamics low wss dolichoectatic aneurysm |
| url | https://www.jstage.jst.go.jp/article/nmc/63/6/63_2023-0005/_pdf/-char/en |
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