Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination
BACKGROUND: This study was conducted to compare the success rate of daily administration of aromatase inhibitor letrozole at a dose of 5 mg when administrating clomiphene citrate (CC) 100 mg daily in women undergoing superovulation and IUI. METHODS: This prospective randomized trial was don...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2006-12-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/24 |
| _version_ | 1828352365049151488 |
|---|---|
| author | Robab Davar Maryam Asgharnia Mojgan J Tayebi |
| author_facet | Robab Davar Maryam Asgharnia Mojgan J Tayebi |
| author_sort | Robab Davar |
| collection | DOAJ |
| description | BACKGROUND: This study was conducted to compare the success rate of daily administration of aromatase inhibitor letrozole at a dose of 5 mg when administrating clomiphene citrate (CC) 100 mg daily in women undergoing superovulation and IUI. METHODS: This prospective randomized trial was done in Research and Clinical Center for Infertility (Shahid Sadoughi University), Yazd, Iran. Ninety-five patients with unexplained and mild male factor infertility were studied. Using a computer-generated random table, the patients were randomized into two groups, which were treated with 5 mg of letrozole daily (42 patients, 42 cycles) or 100 mg of CC daily (53 patients, 53 cycles). The data were analyzed using Student's t-test and chi square test. RESULTS: The mean age and duration of infertility in both groups were similar. There was a significant difference between the two groups in the total numbers of follicles during stimulation (5.45 ± 4.2 in CC group vs. 3.07 ± 2.1 in letrozole group) (P = 0.01). No significant difference in the endometrial thickness was found between the two groups (letrozole group = 6.9 ± 2.2, CC group = 7.8 ± 1.8). The mean levels of LH and FSH in both groups were similar. P value of difference in hormone levels between two groups were 0.33 and 0.47, respectively, but there was a significant difference in mean E2 levels between the two groups (241.28 ± 167.537 in letrozole group vs. 867.34 ± 296.689 in CC group) (P = 0.018). The mean number of gonadotropin ampules used in both groups was the same. Pregnancy rate per cycle was 9.5% in the letrozole group and 5.7% in the CC group (P = 0.6). Two out of the three pregnancies in the CC group (66.6%) and one out of the four pregnancies in the letrozole group resulted in a miscarriage (25%). One twin pregnancy (33%) occurred in the letrozole group and none in the CC group. Ovarian hyperstimulation syndrome (OHSS) did not occur in either of the two groups. CONCLUSIONS: In IUI, superovulation with clomiphene citrate and letrozole was associated with similar pregnancy rates, but the miscarriage rate was higher with clomiphene citrate. KEY WORDS: IUI, letrozole, clomiphene citrate, superovulation. |
| first_indexed | 2024-04-14T01:52:38Z |
| format | Article |
| id | doaj.art-99f2b4ca507143bdaaf953b5de38f38a |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-14T01:52:38Z |
| publishDate | 2006-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-99f2b4ca507143bdaaf953b5de38f38a2022-12-22T02:19:17ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362006-12-01116382387Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine inseminationRobab DavarMaryam AsgharniaMojgan J TayebiBACKGROUND: This study was conducted to compare the success rate of daily administration of aromatase inhibitor letrozole at a dose of 5 mg when administrating clomiphene citrate (CC) 100 mg daily in women undergoing superovulation and IUI. METHODS: This prospective randomized trial was done in Research and Clinical Center for Infertility (Shahid Sadoughi University), Yazd, Iran. Ninety-five patients with unexplained and mild male factor infertility were studied. Using a computer-generated random table, the patients were randomized into two groups, which were treated with 5 mg of letrozole daily (42 patients, 42 cycles) or 100 mg of CC daily (53 patients, 53 cycles). The data were analyzed using Student's t-test and chi square test. RESULTS: The mean age and duration of infertility in both groups were similar. There was a significant difference between the two groups in the total numbers of follicles during stimulation (5.45 ± 4.2 in CC group vs. 3.07 ± 2.1 in letrozole group) (P = 0.01). No significant difference in the endometrial thickness was found between the two groups (letrozole group = 6.9 ± 2.2, CC group = 7.8 ± 1.8). The mean levels of LH and FSH in both groups were similar. P value of difference in hormone levels between two groups were 0.33 and 0.47, respectively, but there was a significant difference in mean E2 levels between the two groups (241.28 ± 167.537 in letrozole group vs. 867.34 ± 296.689 in CC group) (P = 0.018). The mean number of gonadotropin ampules used in both groups was the same. Pregnancy rate per cycle was 9.5% in the letrozole group and 5.7% in the CC group (P = 0.6). Two out of the three pregnancies in the CC group (66.6%) and one out of the four pregnancies in the letrozole group resulted in a miscarriage (25%). One twin pregnancy (33%) occurred in the letrozole group and none in the CC group. Ovarian hyperstimulation syndrome (OHSS) did not occur in either of the two groups. CONCLUSIONS: In IUI, superovulation with clomiphene citrate and letrozole was associated with similar pregnancy rates, but the miscarriage rate was higher with clomiphene citrate. KEY WORDS: IUI, letrozole, clomiphene citrate, superovulation.http://journals.mui.ac.ir/jrms/article/view/24IUI, letrozole, clomiphene citrate, superovulation. |
| spellingShingle | Robab Davar Maryam Asgharnia Mojgan J Tayebi Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination Journal of Research in Medical Sciences IUI, letrozole, clomiphene citrate, superovulation. |
| title | Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| title_full | Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| title_fullStr | Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| title_full_unstemmed | Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| title_short | Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| title_sort | comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination |
| topic | IUI, letrozole, clomiphene citrate, superovulation. |
| url | http://journals.mui.ac.ir/jrms/article/view/24 |
| work_keys_str_mv | AT robabdavar comparisonofthesuccessrateofletrozoleandclomiphenecitrateinwomenundergoingintrauterineinsemination AT maryamasgharnia comparisonofthesuccessrateofletrozoleandclomiphenecitrateinwomenundergoingintrauterineinsemination AT mojganjtayebi comparisonofthesuccessrateofletrozoleandclomiphenecitrateinwomenundergoingintrauterineinsemination |