Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury
Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the injury in the spine. Stem cell therapy is a pro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Veterinary and Animal Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451943X23000352 |
| _version_ | 1797401703057719296 |
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| author | Eun Young Kim Tae Young Kil Min Kyu Kim |
| author_facet | Eun Young Kim Tae Young Kil Min Kyu Kim |
| author_sort | Eun Young Kim |
| collection | DOAJ |
| description | Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the injury in the spine. Stem cell therapy is a promising avenue for SCI research. In this report, we investigate the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog presented with sensory and motor incomplete symptoms resulting in an inability to control the legs, hips, and genitourinary system due to an injury in the lumbar region of the spinal cord. In addition to the administration of surgical decompression, AF-MSCs were directly injected into the damaged spinal tissue. Approximately 15–16 weeks after stem cell transplantation, the dog's hind limb movement improved, and spinal cord regeneration was confirmed through magnetic resonance imaging (MRI). Eventually, the dog was able to walk independently, although not perfectly. In conclusion, AF-MSC-based stem cell transplantation may be beneficial for SCIs. |
| first_indexed | 2024-03-09T02:14:54Z |
| format | Article |
| id | doaj.art-99f38e9a80a14b43b144c54ff37c09aa |
| institution | Directory Open Access Journal |
| issn | 2451-943X |
| language | English |
| last_indexed | 2024-03-09T02:14:54Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Veterinary and Animal Science |
| spelling | doaj.art-99f38e9a80a14b43b144c54ff37c09aa2023-12-07T05:29:40ZengElsevierVeterinary and Animal Science2451-943X2023-12-0122100318Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injuryEun Young Kim0Tae Young Kil1Min Kyu Kim2MKbiotech Co., Ltd. , 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of KoreaDepartment of Social Welfare, Joongbu University, Geumsan-gun, Chungcheongnam-do 32713, Republic of KoreaMKbiotech Co., Ltd. , 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea; Division of Animal and Dairy Science, College of Agriculture and Life Science, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea; Corresponding author at: Division of Animal and Dairy Science, College of Agriculture and Life Science, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the injury in the spine. Stem cell therapy is a promising avenue for SCI research. In this report, we investigate the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog presented with sensory and motor incomplete symptoms resulting in an inability to control the legs, hips, and genitourinary system due to an injury in the lumbar region of the spinal cord. In addition to the administration of surgical decompression, AF-MSCs were directly injected into the damaged spinal tissue. Approximately 15–16 weeks after stem cell transplantation, the dog's hind limb movement improved, and spinal cord regeneration was confirmed through magnetic resonance imaging (MRI). Eventually, the dog was able to walk independently, although not perfectly. In conclusion, AF-MSC-based stem cell transplantation may be beneficial for SCIs.http://www.sciencedirect.com/science/article/pii/S2451943X23000352Canine (dog)Spinal cord injuryAmniotic fluidMesenchymal stem cellsStem cell therapy |
| spellingShingle | Eun Young Kim Tae Young Kil Min Kyu Kim Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury Veterinary and Animal Science Canine (dog) Spinal cord injury Amniotic fluid Mesenchymal stem cells Stem cell therapy |
| title | Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| title_full | Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| title_fullStr | Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| title_full_unstemmed | Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| title_short | Case report: Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| title_sort | case report amniotic fluid derived mesenchymal stem cell treatment in a dog with a spinal cord injury |
| topic | Canine (dog) Spinal cord injury Amniotic fluid Mesenchymal stem cells Stem cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2451943X23000352 |
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