Infectious agents in the pathogenesis of rosacea
Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopustular phase and a phymatous type in the final stages. An ocular type of rosacea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-09-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Infectious-agents-in-the-pathogenesis-of-rosacea,56,28157,1,1.html |
| Summary: | Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopustular phase and a phymatous type in the final stages. An ocular type of rosacea is described in the literature as well. In the etiopathogenesis of papulo-pustular and ocular types of rosacea, inflammatory response modulation caused by microorganisms living on the skin play a key role. Binding of bacterial ligands with epidermal receptors leads to induction of the inflammatory cascade. This leads to vasodilation and white blood cell chemotaxis, which causes a change in the microenvironment of the skin that assists in microorganism proliferation. Microorganisms such as Demodex folliculorum, Bacillus oleronius, Staphylococcus epidermidis, Chlamydia pneumoniae and Helicobacter pylori play a crucial role in the pathogenesis of rosacea. |
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| ISSN: | 0033-2526 2084-9893 |