Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice
Considering the beneficial effects of Apium graveolens L. (Celery) on the nervous system, this study elucidates the protective effect of CEO on the experimental model of cuprizone-induced MS in male C57BL/6 mice. Frothy mice were allocated into four experimental groups: control, cuprizone (chew pell...
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| Format: | Article |
| Language: | English |
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Ferdowsi University of Mashhad
2023-07-01
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| Series: | The Iranian Journal of Veterinary Science and Technology |
| Subjects: | |
| Online Access: | https://ijvst.um.ac.ir/article_43936_c2edac38b0e7c70627adfd72128ceee1.pdf |
| _version_ | 1797768910252015616 |
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| author | Tahoura Mohammadi-Ghohaki Shahin Hassanpour Morteza Zendedel kheybari |
| author_facet | Tahoura Mohammadi-Ghohaki Shahin Hassanpour Morteza Zendedel kheybari |
| author_sort | Tahoura Mohammadi-Ghohaki |
| collection | DOAJ |
| description | Considering the beneficial effects of Apium graveolens L. (Celery) on the nervous system, this study elucidates the protective effect of CEO on the experimental model of cuprizone-induced MS in male C57BL/6 mice. Frothy mice were allocated into four experimental groups: control, cuprizone (chew pellet containing 0.2 %CPZ), CEO (800 mg/kg), and CPZ+CEO. Animals received treatments based on their groups for 5 weeks. Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on the findings, ambulation score, hind-limb suspension, front limb suspension, and grip strength significantly decreed in the mice treated with CPZ (p < 0.05). Hind limb foot angle, surface rights, and negative geotaxis significantly increased in the animals treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on ambulation score, surface righting, hind limb suspension, grip strength, and negative geotaxis (p < 0.05). Co-administration of CPZ+CEO significantly diminished the adverse effects of CPZ on the number of crosses in the open field test and duration on the rotarod (p < 0.05). Serum MDA activity increased while GPx, SOD, and TAS decreased in the mice treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on serum antioxidant levels (p < 0.05). These results suggested the protective effect of CEO against CPZ-induced MS mediated by its antioxidant activity. |
| first_indexed | 2024-03-12T21:01:12Z |
| format | Article |
| id | doaj.art-99f41a0c7aea4f0fa31d5f64e1a58ac7 |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-03-12T21:01:12Z |
| publishDate | 2023-07-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-99f41a0c7aea4f0fa31d5f64e1a58ac72023-07-31T07:41:17ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062023-07-01152566610.22067/ijvst.2023.78858.119143936Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 MiceTahoura Mohammadi-Ghohaki0Shahin Hassanpour1Morteza Zendedel kheybari2Graduate student, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran.Considering the beneficial effects of Apium graveolens L. (Celery) on the nervous system, this study elucidates the protective effect of CEO on the experimental model of cuprizone-induced MS in male C57BL/6 mice. Frothy mice were allocated into four experimental groups: control, cuprizone (chew pellet containing 0.2 %CPZ), CEO (800 mg/kg), and CPZ+CEO. Animals received treatments based on their groups for 5 weeks. Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on the findings, ambulation score, hind-limb suspension, front limb suspension, and grip strength significantly decreed in the mice treated with CPZ (p < 0.05). Hind limb foot angle, surface rights, and negative geotaxis significantly increased in the animals treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on ambulation score, surface righting, hind limb suspension, grip strength, and negative geotaxis (p < 0.05). Co-administration of CPZ+CEO significantly diminished the adverse effects of CPZ on the number of crosses in the open field test and duration on the rotarod (p < 0.05). Serum MDA activity increased while GPx, SOD, and TAS decreased in the mice treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on serum antioxidant levels (p < 0.05). These results suggested the protective effect of CEO against CPZ-induced MS mediated by its antioxidant activity.https://ijvst.um.ac.ir/article_43936_c2edac38b0e7c70627adfd72128ceee1.pdfceleryessential oilcuprizonemultiple sclerosismice |
| spellingShingle | Tahoura Mohammadi-Ghohaki Shahin Hassanpour Morteza Zendedel kheybari Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice The Iranian Journal of Veterinary Science and Technology celery essential oil cuprizone multiple sclerosis mice |
| title | Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice |
| title_full | Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice |
| title_fullStr | Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice |
| title_full_unstemmed | Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice |
| title_short | Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice |
| title_sort | protective effect of celery apium graveolens l essential oil on the experimental model of cuprizone induced multiple sclerosis in male c57bl 6 mice |
| topic | celery essential oil cuprizone multiple sclerosis mice |
| url | https://ijvst.um.ac.ir/article_43936_c2edac38b0e7c70627adfd72128ceee1.pdf |
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