A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
Abstract Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in different animal species. Although mice exhibit limited cooperative capacity in some...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-023-01032-y |
| _version_ | 1797827256024825856 |
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| author | Ke-Ming Zhang Yan Shen Chun-Hui Jia Hao Wang Guo-Qiang Bi Pak-Ming Lau |
| author_facet | Ke-Ming Zhang Yan Shen Chun-Hui Jia Hao Wang Guo-Qiang Bi Pak-Ming Lau |
| author_sort | Ke-Ming Zhang |
| collection | DOAJ |
| description | Abstract Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in different animal species. Although mice exhibit limited cooperative capacity in some behavioral paradigms, it is still interesting to explore their cooperative behavior and the underlying neural mechanisms. Here, we developed a new paradigm for training and testing cooperative behavior in mice based on coordinated lever-pressing and analyzed social interactions between the animals during cooperation. We observed extensive social contact and waiting behavior in cooperating animals, with the number of such events positively correlated with the success of cooperation. Using c-Fos immunostaining and a high-speed volumetric imaging with synchronized on-the-fly scan and readout (VISoR) system, we further mapped whole-brain neuronal activity trace following cooperation. Significantly higher levels of c-Fos expression were observed in cortical areas including the frontal pole, motor cortex, anterior cingulate area, and prelimbic area. These observations highlight social interaction and coordination in cooperative behavior and provide clues for further study of the underlying neural circuitry mechanisms. |
| first_indexed | 2024-04-09T12:46:23Z |
| format | Article |
| id | doaj.art-99f44110fd644069ad7712a21c613d3a |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-04-09T12:46:23Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-99f44110fd644069ad7712a21c613d3a2023-05-14T11:31:41ZengBMCMolecular Brain1756-66062023-05-011611610.1186/s13041-023-01032-yA new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in miceKe-Ming Zhang0Yan Shen1Chun-Hui Jia2Hao Wang3Guo-Qiang Bi4Pak-Ming Lau5CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of ChinaNational Engineering Laboratory for Brain-Inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of ChinaCAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of ChinaAbstract Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in different animal species. Although mice exhibit limited cooperative capacity in some behavioral paradigms, it is still interesting to explore their cooperative behavior and the underlying neural mechanisms. Here, we developed a new paradigm for training and testing cooperative behavior in mice based on coordinated lever-pressing and analyzed social interactions between the animals during cooperation. We observed extensive social contact and waiting behavior in cooperating animals, with the number of such events positively correlated with the success of cooperation. Using c-Fos immunostaining and a high-speed volumetric imaging with synchronized on-the-fly scan and readout (VISoR) system, we further mapped whole-brain neuronal activity trace following cooperation. Significantly higher levels of c-Fos expression were observed in cortical areas including the frontal pole, motor cortex, anterior cingulate area, and prelimbic area. These observations highlight social interaction and coordination in cooperative behavior and provide clues for further study of the underlying neural circuitry mechanisms.https://doi.org/10.1186/s13041-023-01032-yCooperationSocial interactionc-FosNeuronal activity traceVISoR |
| spellingShingle | Ke-Ming Zhang Yan Shen Chun-Hui Jia Hao Wang Guo-Qiang Bi Pak-Ming Lau A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice Molecular Brain Cooperation Social interaction c-Fos Neuronal activity trace VISoR |
| title | A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| title_full | A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| title_fullStr | A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| title_full_unstemmed | A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| title_short | A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| title_sort | new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice |
| topic | Cooperation Social interaction c-Fos Neuronal activity trace VISoR |
| url | https://doi.org/10.1186/s13041-023-01032-y |
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