Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases
Abstract Background Since humoral hypercalcemia of malignancy (HHM) in breast cancer patients without bone metastasis is rare, the clinical features of this condition are not fully understood. Case presentation During the recent 12 years, 3602 patients were diagnosed with breast cancer in our instit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-11-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40792-022-01565-9 |
| _version_ | 1797986793071575040 |
|---|---|
| author | Sakina Hashizume Masafumi Shimoda Tetsuhiro Yoshinami Kaori Abe Nanae Masunaga Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Kenzo Shimazu |
| author_facet | Sakina Hashizume Masafumi Shimoda Tetsuhiro Yoshinami Kaori Abe Nanae Masunaga Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Kenzo Shimazu |
| author_sort | Sakina Hashizume |
| collection | DOAJ |
| description | Abstract Background Since humoral hypercalcemia of malignancy (HHM) in breast cancer patients without bone metastasis is rare, the clinical features of this condition are not fully understood. Case presentation During the recent 12 years, 3602 patients were diagnosed with breast cancer in our institution, and only three patients developed HHM without bone metastasis. They were all recurrent breast cancer patients with visceral metastases including the lung and the liver. It took no more than 2 months since symptomatic onset to hospitalization because of hypercalcemia. The maximum serum calcium concentrations were 15.0 mg/dL or higher. All patients had symptoms related to hypercalcemia. Treatment of hypercalcemia including hydration, calcitonin, bisphosphonate, and diuretics was initially effective in the three patients. However, two of three cases were eventually fatal because of unsuccessful treatment of breast cancer. Conclusions The common features of HHM without bone metastasis in breast cancer patients include acute onset, severe symptomatic hypercalcemia, and presence of visceral metastasis. Treatment of hypercalcemia decreased serum calcium level in a short period, while successful treatment of breast cancer was essential for a long-term management of HHM. This report provides a consideration to help elucidate the pathophysiology and medical care of breast cancer patients with HHM without bone metastasis. |
| first_indexed | 2024-04-11T07:38:39Z |
| format | Article |
| id | doaj.art-99f8a25b55544e639cc9a37f0bfcc515 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-04-11T07:38:39Z |
| publishDate | 2022-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-99f8a25b55544e639cc9a37f0bfcc5152022-12-22T04:36:39ZengSpringerOpenSurgical Case Reports2198-77932022-11-01811610.1186/s40792-022-01565-9Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three casesSakina Hashizume0Masafumi Shimoda1Tetsuhiro Yoshinami2Kaori Abe3Nanae Masunaga4Yoshiaki Sota5Tomohiro Miyake6Tomonori Tanei7Kenzo Shimazu8Department of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineAbstract Background Since humoral hypercalcemia of malignancy (HHM) in breast cancer patients without bone metastasis is rare, the clinical features of this condition are not fully understood. Case presentation During the recent 12 years, 3602 patients were diagnosed with breast cancer in our institution, and only three patients developed HHM without bone metastasis. They were all recurrent breast cancer patients with visceral metastases including the lung and the liver. It took no more than 2 months since symptomatic onset to hospitalization because of hypercalcemia. The maximum serum calcium concentrations were 15.0 mg/dL or higher. All patients had symptoms related to hypercalcemia. Treatment of hypercalcemia including hydration, calcitonin, bisphosphonate, and diuretics was initially effective in the three patients. However, two of three cases were eventually fatal because of unsuccessful treatment of breast cancer. Conclusions The common features of HHM without bone metastasis in breast cancer patients include acute onset, severe symptomatic hypercalcemia, and presence of visceral metastasis. Treatment of hypercalcemia decreased serum calcium level in a short period, while successful treatment of breast cancer was essential for a long-term management of HHM. This report provides a consideration to help elucidate the pathophysiology and medical care of breast cancer patients with HHM without bone metastasis.https://doi.org/10.1186/s40792-022-01565-9Humoral hypercalcemia of malignancyBreast cancerPTHrPLocal osteolytic hypercalcemia |
| spellingShingle | Sakina Hashizume Masafumi Shimoda Tetsuhiro Yoshinami Kaori Abe Nanae Masunaga Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Kenzo Shimazu Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases Surgical Case Reports Humoral hypercalcemia of malignancy Breast cancer PTHrP Local osteolytic hypercalcemia |
| title | Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases |
| title_full | Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases |
| title_fullStr | Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases |
| title_full_unstemmed | Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases |
| title_short | Hypercalcemia affected in metastatic breast cancer patients without bone metastasis: report of three cases |
| title_sort | hypercalcemia affected in metastatic breast cancer patients without bone metastasis report of three cases |
| topic | Humoral hypercalcemia of malignancy Breast cancer PTHrP Local osteolytic hypercalcemia |
| url | https://doi.org/10.1186/s40792-022-01565-9 |
| work_keys_str_mv | AT sakinahashizume hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT masafumishimoda hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT tetsuhiroyoshinami hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT kaoriabe hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT nanaemasunaga hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT yoshiakisota hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT tomohiromiyake hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT tomonoritanei hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases AT kenzoshimazu hypercalcemiaaffectedinmetastaticbreastcancerpatientswithoutbonemetastasisreportofthreecases |