Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging
Abstract This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non‐invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar‐Han, n = 3 Sprague–Dawley) were imaged and both male and female rats were included. The...
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Pharmacology Research & Perspectives |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prp2.731 |
| _version_ | 1818918502461865984 |
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| author | Christopher R. Gibson Alexa Gleason Eric Messina |
| author_facet | Christopher R. Gibson Alexa Gleason Eric Messina |
| author_sort | Christopher R. Gibson |
| collection | DOAJ |
| description | Abstract This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non‐invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar‐Han, n = 3 Sprague–Dawley) were imaged and both male and female rats were included. The mean (SD) total liver blood flow of all animals combined was 33.3 ± 7.8 mL/min, or 104.3 ± 17.1 mL/min/kg when normalized to observed body weight at the time of imaging. There was a trend for higher unnormalized total liver blood flow as body weight increased and the female rats had, in general, the lowest body weight and total liver blood flow of the animals studied. There were no major differences in total liver blood flow between the small number of Sprague–Dawley rats used in the study and the larger Wistar‐Han group. Further research would be needed to accurately characterize any subtle differences in body weight between rats of different strains, sexes, and body weight. |
| first_indexed | 2024-12-20T00:50:59Z |
| format | Article |
| id | doaj.art-99f9c6df3f204338ada0d02e4d6796ff |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-12-20T00:50:59Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-99f9c6df3f204338ada0d02e4d6796ff2022-12-21T19:59:15ZengWileyPharmacology Research & Perspectives2052-17072021-04-0192n/an/a10.1002/prp2.731Measurement of total liver blood flow in intact anesthetized rats using ultrasound imagingChristopher R. Gibson0Alexa Gleason1Eric Messina2Departments of Pharmacokinetics Pharmacodynamics and Drug Metabolism (CRG) Translational Biomarkers (AG, EM)Merck & Co., Inc. West Point PA USADepartments of Pharmacokinetics Pharmacodynamics and Drug Metabolism (CRG) Translational Biomarkers (AG, EM)Merck & Co., Inc. West Point PA USADepartments of Pharmacokinetics Pharmacodynamics and Drug Metabolism (CRG) Translational Biomarkers (AG, EM)Merck & Co., Inc. West Point PA USAAbstract This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non‐invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar‐Han, n = 3 Sprague–Dawley) were imaged and both male and female rats were included. The mean (SD) total liver blood flow of all animals combined was 33.3 ± 7.8 mL/min, or 104.3 ± 17.1 mL/min/kg when normalized to observed body weight at the time of imaging. There was a trend for higher unnormalized total liver blood flow as body weight increased and the female rats had, in general, the lowest body weight and total liver blood flow of the animals studied. There were no major differences in total liver blood flow between the small number of Sprague–Dawley rats used in the study and the larger Wistar‐Han group. Further research would be needed to accurately characterize any subtle differences in body weight between rats of different strains, sexes, and body weight.https://doi.org/10.1002/prp2.731blood flowliverratultrasound |
| spellingShingle | Christopher R. Gibson Alexa Gleason Eric Messina Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging Pharmacology Research & Perspectives blood flow liver rat ultrasound |
| title | Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| title_full | Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| title_fullStr | Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| title_full_unstemmed | Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| title_short | Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| title_sort | measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging |
| topic | blood flow liver rat ultrasound |
| url | https://doi.org/10.1002/prp2.731 |
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