Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress
Diabetes mellitus (DM) is a severe chronic metabolic disease with increased mortality and morbidity. The pathological progression of DM is intimately connected with the formation and activation of oxidative stress (OS). Especially, the involvement of OS with hyperglycemia, insulin resistance, and in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7115 |
| _version_ | 1797507442598215680 |
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| author | Yu Xu Guoyi Tang Cheng Zhang Ning Wang Yibin Feng |
| author_facet | Yu Xu Guoyi Tang Cheng Zhang Ning Wang Yibin Feng |
| author_sort | Yu Xu |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a severe chronic metabolic disease with increased mortality and morbidity. The pathological progression of DM is intimately connected with the formation and activation of oxidative stress (OS). Especially, the involvement of OS with hyperglycemia, insulin resistance, and inflammation has shown a vital role in the pathophysiological development of DM and related complications. Interestingly, accumulating studies have focused on the exploration of natural antioxidants for their improvement on DM. Of specific interest is gallic acid (GA), which is rich in many edible and herbal plants and has progressively demonstrated robust antioxidative and anti-inflammatory effects on metabolic disorders. To provide a better understanding of its potential therapeutic impacts and enhancement of human health care, the available research evidence supporting the effective antidiabetic properties of GA and relevant derivatives are needed to be summarized and discussed, with emphasis on its regulation on OS and inflammation against DM. This review aims to highlight the latest viewpoints and current research information on the role of OS in diabetes and to provide scientific support for GA as a potential antihypoglycemic agent for DM and its complications. |
| first_indexed | 2024-03-10T04:48:32Z |
| format | Article |
| id | doaj.art-99fa370e99fa44049d5d556b98e783bb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:48:32Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-99fa370e99fa44049d5d556b98e783bb2023-11-23T02:47:35ZengMDPI AGMolecules1420-30492021-11-012623711510.3390/molecules26237115Gallic Acid and Diabetes Mellitus: Its Association with Oxidative StressYu Xu0Guoyi Tang1Cheng Zhang2Ning Wang3Yibin Feng4School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDiabetes mellitus (DM) is a severe chronic metabolic disease with increased mortality and morbidity. The pathological progression of DM is intimately connected with the formation and activation of oxidative stress (OS). Especially, the involvement of OS with hyperglycemia, insulin resistance, and inflammation has shown a vital role in the pathophysiological development of DM and related complications. Interestingly, accumulating studies have focused on the exploration of natural antioxidants for their improvement on DM. Of specific interest is gallic acid (GA), which is rich in many edible and herbal plants and has progressively demonstrated robust antioxidative and anti-inflammatory effects on metabolic disorders. To provide a better understanding of its potential therapeutic impacts and enhancement of human health care, the available research evidence supporting the effective antidiabetic properties of GA and relevant derivatives are needed to be summarized and discussed, with emphasis on its regulation on OS and inflammation against DM. This review aims to highlight the latest viewpoints and current research information on the role of OS in diabetes and to provide scientific support for GA as a potential antihypoglycemic agent for DM and its complications.https://www.mdpi.com/1420-3049/26/23/7115diabetes mellitusoxidative stressinflammationgallic acid |
| spellingShingle | Yu Xu Guoyi Tang Cheng Zhang Ning Wang Yibin Feng Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress Molecules diabetes mellitus oxidative stress inflammation gallic acid |
| title | Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress |
| title_full | Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress |
| title_fullStr | Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress |
| title_full_unstemmed | Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress |
| title_short | Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress |
| title_sort | gallic acid and diabetes mellitus its association with oxidative stress |
| topic | diabetes mellitus oxidative stress inflammation gallic acid |
| url | https://www.mdpi.com/1420-3049/26/23/7115 |
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