Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology
Aim: to evaluate features of the functional state of microvascular bed of the skin in patients with pulmonary arterial hypertension associated to congenital cardiac disease (PAH-CCD) and chronic thromboembolic pulmonary hypertension (CTEPH). Methods. In study included 25 patients (41.6±15.8) with...
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| Format: | Article |
| Language: | Russian |
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IP Morozov P.V.
2016-08-01
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| Series: | Системные гипертензии |
| Subjects: | |
| Online Access: | http://syst-hypertension.ru/en/archive/2016/vol-13-3-2016/features-of-cutaneous-microcirculatory-blood-flow-in-patients-with-pulmonary-hypertension-of-differe_1920/ |
| _version_ | 1818662022338838528 |
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| author | Dolgova E.V. Fedorovich A.A. Martynyuk T.V. |
| author_facet | Dolgova E.V. Fedorovich A.A. Martynyuk T.V. |
| author_sort | Dolgova E.V. |
| collection | DOAJ |
| description | Aim: to evaluate features of the functional state of microvascular bed of the skin in patients with pulmonary arterial hypertension associated to congenital cardiac disease (PAH-CCD) and chronic thromboembolic pulmonary hypertension (CTEPH).
Methods. In study included 25 patients (41.6±15.8) with PAH-CCD, 25 patients (48.8±14.2) with CTEPH and 25 healthy volunteers (39.3±10.1 years). All the patients underwent a six-minute walking test (6-MWT), transthoracic echocardiography, thorax organs radiography, right heart catheterization (RHC) and Laser Doppler flowmetry (LDF) with amplitude and frequency wavelet analysis of blood flow oscillations and evaluation of constrictory and dilatatoryskin resistive microvesselsfunctions.
Results. In the PAH-CCD in relation to the CTEPH groupaccording to the RHC were noted significantly higher values of systolic pressure in pulmonary artery (93.2 and 77.8 mm Hg respectively) and venous mixted blood saturation(63 and 57% Hg respectively). On this background 6-MWT distance was 356 and 325 m, the Borg dyspnea scale index was on average 3.12 and 3.76 respectively. According to the LDF pulseoximetry PAH-CCD and CTEPH patients had 90.1 and 94.7% respectively. According to the LDF with amplitude and frequency wavelet analysis the PAH-CCD patients had significantly higher values of the amplitude of myogenic, respiratory and pulse sectionof blood flow modulation, and also increased constrictory activity smooth muscle cells of skin precapillary arterioles in response to the stretching at venous occlusion and decreased dilatatory reserve at post-occlusive reactive hyperemia. According to the LDF the CTEPH patients had elongationof time development of microvessel constriction in response to activation of sympathetic nervous systemin respiratory and cold tests.
Conclusion. According to the LDF functional state of skin microvessels in systemic circulation of the CTEPH patients was comparable with control groupexcept for elongation of time development of microvessel reactions for sympathetic vasoconstrictor stimulations. The PAH-CCD patients demonstrated basal tonus decreasing of smooth muscle cells of skin precapillary arterioles in systemic circulation, which can be regarded as a manifestation of autoregulatory response to systemic hypoxia. |
| first_indexed | 2024-12-17T04:54:20Z |
| format | Article |
| id | doaj.art-99fa9b1f27224e87aa182b1a16622c35 |
| institution | Directory Open Access Journal |
| issn | 2075-082X 2542-2189 |
| language | Russian |
| last_indexed | 2024-12-17T04:54:20Z |
| publishDate | 2016-08-01 |
| publisher | IP Morozov P.V. |
| record_format | Article |
| series | Системные гипертензии |
| spelling | doaj.art-99fa9b1f27224e87aa182b1a16622c352022-12-21T22:02:47ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892016-08-01133354110.26442/2075-082X_13.3.35-41Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiologyDolgova E.V.0Fedorovich A.A.1Martynyuk T.V.2A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation. 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15aA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation. 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15aA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation. 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15aAim: to evaluate features of the functional state of microvascular bed of the skin in patients with pulmonary arterial hypertension associated to congenital cardiac disease (PAH-CCD) and chronic thromboembolic pulmonary hypertension (CTEPH). Methods. In study included 25 patients (41.6±15.8) with PAH-CCD, 25 patients (48.8±14.2) with CTEPH and 25 healthy volunteers (39.3±10.1 years). All the patients underwent a six-minute walking test (6-MWT), transthoracic echocardiography, thorax organs radiography, right heart catheterization (RHC) and Laser Doppler flowmetry (LDF) with amplitude and frequency wavelet analysis of blood flow oscillations and evaluation of constrictory and dilatatoryskin resistive microvesselsfunctions. Results. In the PAH-CCD in relation to the CTEPH groupaccording to the RHC were noted significantly higher values of systolic pressure in pulmonary artery (93.2 and 77.8 mm Hg respectively) and venous mixted blood saturation(63 and 57% Hg respectively). On this background 6-MWT distance was 356 and 325 m, the Borg dyspnea scale index was on average 3.12 and 3.76 respectively. According to the LDF pulseoximetry PAH-CCD and CTEPH patients had 90.1 and 94.7% respectively. According to the LDF with amplitude and frequency wavelet analysis the PAH-CCD patients had significantly higher values of the amplitude of myogenic, respiratory and pulse sectionof blood flow modulation, and also increased constrictory activity smooth muscle cells of skin precapillary arterioles in response to the stretching at venous occlusion and decreased dilatatory reserve at post-occlusive reactive hyperemia. According to the LDF the CTEPH patients had elongationof time development of microvessel constriction in response to activation of sympathetic nervous systemin respiratory and cold tests. Conclusion. According to the LDF functional state of skin microvessels in systemic circulation of the CTEPH patients was comparable with control groupexcept for elongation of time development of microvessel reactions for sympathetic vasoconstrictor stimulations. The PAH-CCD patients demonstrated basal tonus decreasing of smooth muscle cells of skin precapillary arterioles in systemic circulation, which can be regarded as a manifestation of autoregulatory response to systemic hypoxia.http://syst-hypertension.ru/en/archive/2016/vol-13-3-2016/features-of-cutaneous-microcirculatory-blood-flow-in-patients-with-pulmonary-hypertension-of-differe_1920/pulmonary arterial hypertension associated to congenital cardiac diseasechronic thromboembolic pulmonary hypertensionmicrocirculation in the skinlaser Doppler flowmetry |
| spellingShingle | Dolgova E.V. Fedorovich A.A. Martynyuk T.V. Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology Системные гипертензии pulmonary arterial hypertension associated to congenital cardiac disease chronic thromboembolic pulmonary hypertension microcirculation in the skin laser Doppler flowmetry |
| title | Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| title_full | Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| title_fullStr | Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| title_full_unstemmed | Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| title_short | Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| title_sort | features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology |
| topic | pulmonary arterial hypertension associated to congenital cardiac disease chronic thromboembolic pulmonary hypertension microcirculation in the skin laser Doppler flowmetry |
| url | http://syst-hypertension.ru/en/archive/2016/vol-13-3-2016/features-of-cutaneous-microcirculatory-blood-flow-in-patients-with-pulmonary-hypertension-of-differe_1920/ |
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