Decreased Levels of GSH Are Associated with Platinum Resistance in High-Grade Serous Ovarian Cancer

Decreased Levels of GSH Are Associated with Platinum Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive OC histotype. Although initially sensitive to standard platinum-based chemotherapy, most HGSOC patients relapse and become chemoresistant. We have previously demonstrated that platinum resistance is driven by a metabolic shif...

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Bibliographic Details
Main Authors: Daniela Criscuolo, Rosario Avolio, Matteo Parri, Simona Romano, Paola Chiarugi, Danilo Swann Matassa, Franca Esposito
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
ovarian cancer
platinum resistance
GSH
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2076-3921/11/8/1544

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