Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease
The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the develo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2243 |
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| author | Elisabet Navarro-Tapia Giorgia Sebastiani Sebastian Sailer Laura Almeida Toledano Mariona Serra-Delgado Óscar García-Algar Vicente Andreu-Fernández |
| author_facet | Elisabet Navarro-Tapia Giorgia Sebastiani Sebastian Sailer Laura Almeida Toledano Mariona Serra-Delgado Óscar García-Algar Vicente Andreu-Fernández |
| author_sort | Elisabet Navarro-Tapia |
| collection | DOAJ |
| description | The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of <i>Lactobacillus</i> and <i>Bifidobacterium</i> strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections. |
| first_indexed | 2024-03-10T18:11:17Z |
| format | Article |
| id | doaj.art-9a02d3fafce742e1a7f1effe1039a47b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:11:17Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9a02d3fafce742e1a7f1effe1039a47b2023-11-20T08:08:11ZengMDPI AGNutrients2072-66432020-07-01128224310.3390/nu12082243Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and DiseaseElisabet Navarro-Tapia0Giorgia Sebastiani1Sebastian Sailer2Laura Almeida Toledano3Mariona Serra-Delgado4Óscar García-Algar5Vicente Andreu-Fernández6Grup de Recerca Infancia i Entorn (GRIE), Institut D’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainDepartment of Neonatology, Hospital Clínic-Maternitat, ICGON, BCNatal, 08028 Barcelona, SpainDepartment of Neonatology, Hospital Clínic-Maternitat, ICGON, BCNatal, 08028 Barcelona, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainGrup de Recerca Infancia i Entorn (GRIE), Institut D’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainGrup de Recerca Infancia i Entorn (GRIE), Institut D’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainThe perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of <i>Lactobacillus</i> and <i>Bifidobacterium</i> strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.https://www.mdpi.com/2072-6643/12/8/2243probioticsgut microbiotadysbiosisantibiotic resistanceautoimmune diseasesatopic diseases |
| spellingShingle | Elisabet Navarro-Tapia Giorgia Sebastiani Sebastian Sailer Laura Almeida Toledano Mariona Serra-Delgado Óscar García-Algar Vicente Andreu-Fernández Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease Nutrients probiotics gut microbiota dysbiosis antibiotic resistance autoimmune diseases atopic diseases |
| title | Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease |
| title_full | Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease |
| title_fullStr | Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease |
| title_full_unstemmed | Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease |
| title_short | Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease |
| title_sort | probiotic supplementation during the perinatal and infant period effects on gut dysbiosis and disease |
| topic | probiotics gut microbiota dysbiosis antibiotic resistance autoimmune diseases atopic diseases |
| url | https://www.mdpi.com/2072-6643/12/8/2243 |
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