MicroRNAs as stress regulators in pancreatic beta cells and diabetes
Background: MicroRNAs have emerged as important regulatory non-coding RNAs that tune cellular responses to physiological perturbations and disease conditions. An increasing body of literature underlines the important roles of miRNA function in pancreatic β-cells in response to metabolic, genetic and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877817302910 |
| _version_ | 1819070995215941632 |
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| author | Mary P. LaPierre Markus Stoffel |
| author_facet | Mary P. LaPierre Markus Stoffel |
| author_sort | Mary P. LaPierre |
| collection | DOAJ |
| description | Background: MicroRNAs have emerged as important regulatory non-coding RNAs that tune cellular responses to physiological perturbations and disease conditions. An increasing body of literature underlines the important roles of miRNA function in pancreatic β-cells in response to metabolic, genetic and inflammatory stress. Lessons from genetic loss- and gain-of-function studies have implicated several highly expressed and evolutionary conserved miRNAs in stress signal modulation, resolution and buffering, thereby forming stabilizing miRNA networks that preserve β-cell differentiation, function, proliferation and cell survival.
Scope of Review: This review will summarize our current knowledge of how biologically relevant miRNAs regulate stress responses in pancreatic β-cells, discuss the challenges and opportunities associated with using secreted miRNAs as biomarkers and forecast how mechanistic knowledge of miRNA function can be exploited in developing miRNA-based therapeutics.
Major Conclusions: miRNAs play important roles in the function, differentiation, proliferation, and survival of pancreatic β-cells. Many miRNA families that are regulated by metabolic, genetic, and inflammatory stressors have been found to coordinate the adaptive responses of β-cells in vivo in conditions such as obesity and diabetes. |
| first_indexed | 2024-12-21T17:14:47Z |
| format | Article |
| id | doaj.art-9a04c0d0087b4992af3b5bcee778de15 |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-12-21T17:14:47Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-9a04c0d0087b4992af3b5bcee778de152022-12-21T18:56:20ZengElsevierMolecular Metabolism2212-87782017-09-01691010102310.1016/j.molmet.2017.06.020MicroRNAs as stress regulators in pancreatic beta cells and diabetesMary P. LaPierreMarkus StoffelBackground: MicroRNAs have emerged as important regulatory non-coding RNAs that tune cellular responses to physiological perturbations and disease conditions. An increasing body of literature underlines the important roles of miRNA function in pancreatic β-cells in response to metabolic, genetic and inflammatory stress. Lessons from genetic loss- and gain-of-function studies have implicated several highly expressed and evolutionary conserved miRNAs in stress signal modulation, resolution and buffering, thereby forming stabilizing miRNA networks that preserve β-cell differentiation, function, proliferation and cell survival. Scope of Review: This review will summarize our current knowledge of how biologically relevant miRNAs regulate stress responses in pancreatic β-cells, discuss the challenges and opportunities associated with using secreted miRNAs as biomarkers and forecast how mechanistic knowledge of miRNA function can be exploited in developing miRNA-based therapeutics. Major Conclusions: miRNAs play important roles in the function, differentiation, proliferation, and survival of pancreatic β-cells. Many miRNA families that are regulated by metabolic, genetic, and inflammatory stressors have been found to coordinate the adaptive responses of β-cells in vivo in conditions such as obesity and diabetes.http://www.sciencedirect.com/science/article/pii/S2212877817302910miRNAsPancreatic β-cellsInsulin secretionDiabetes |
| spellingShingle | Mary P. LaPierre Markus Stoffel MicroRNAs as stress regulators in pancreatic beta cells and diabetes Molecular Metabolism miRNAs Pancreatic β-cells Insulin secretion Diabetes |
| title | MicroRNAs as stress regulators in pancreatic beta cells and diabetes |
| title_full | MicroRNAs as stress regulators in pancreatic beta cells and diabetes |
| title_fullStr | MicroRNAs as stress regulators in pancreatic beta cells and diabetes |
| title_full_unstemmed | MicroRNAs as stress regulators in pancreatic beta cells and diabetes |
| title_short | MicroRNAs as stress regulators in pancreatic beta cells and diabetes |
| title_sort | micrornas as stress regulators in pancreatic beta cells and diabetes |
| topic | miRNAs Pancreatic β-cells Insulin secretion Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2212877817302910 |
| work_keys_str_mv | AT maryplapierre micrornasasstressregulatorsinpancreaticbetacellsanddiabetes AT markusstoffel micrornasasstressregulatorsinpancreaticbetacellsanddiabetes |