Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women
Aim. To study the features of cardiac remodeling on condition of the autonomic nervous system (ANS) in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of the echocardiography data in women with IAH aged 18-25 years with a predominance of sympatheti...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2019-03-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/812 |
| _version_ | 1797882476710854656 |
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| author | V. M. Baev Т. Yu. Agafonova |
| author_facet | V. M. Baev Т. Yu. Agafonova |
| author_sort | V. M. Baev |
| collection | DOAJ |
| description | Aim. To study the features of cardiac remodeling on condition of the autonomic nervous system (ANS) in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of the echocardiography data in women with IAH aged 18-25 years with a predominance of sympathetic (n=150) and parasympathetic (n=60) parts of the ANS was performed. The level of systolic blood pressure ≤98 mm Hg worked as the criterion of IAH. The activity of the ANS was evaluated by the I. Kérdö index.Results. It has been shown that women with IAH with sympathicotonia are characterized by a significant decrease in the structural parameters of the heart: the size of all chambers and the aortic ostium, contractile function decrease and a slower relaxation of the left ventricle (LV). Acceleration of intracardiac hemodynamics was observed: an increase in blood flow rates and pressure gradients on the mitral, tricuspid and pulmonary artery valves, an increase in the rates of early and late diastolic LV filling. Changes in early LV diastole are associated with an increase of pressure in the left atrium. We identified a restrictive type of diastolic dysfunction in women with parasympathicotonia.Conclusion. Sympathicotonia and parasympathicotonia in young women with IAH are associated with different heart remodeling variants. Cardiac hypotrophy, decrease of contractile function and impaired LV relaxation during hypotension are associated with low sympathetic activity against the background of parasympathicotonia. The restrictive type of diastolic dysfunction during hypotension is associated with parasympathicotonia. Use of cholinolytics and anticholinesterase reactivators are the potential way of correction of ANS dysfunction, IAH regression and cardiac remodeling. |
| first_indexed | 2024-04-10T03:35:18Z |
| format | Article |
| id | doaj.art-9a058247c68e42639f69f488d1b4514b |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:35:18Z |
| publishDate | 2019-03-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-9a058247c68e42639f69f488d1b4514b2023-03-13T07:23:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252019-03-01181677210.15829/1728-8800-2019-1-67-72611Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young womenV. M. Baev0Т. Yu. Agafonova1ФГБОУ ВО Пермский государственный медицинский университет им. академика Е. А. Вагнера Минздрава РоссииФГБОУ ВО Пермский государственный медицинский университет им. академика Е. А. Вагнера Минздрава РоссииAim. To study the features of cardiac remodeling on condition of the autonomic nervous system (ANS) in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of the echocardiography data in women with IAH aged 18-25 years with a predominance of sympathetic (n=150) and parasympathetic (n=60) parts of the ANS was performed. The level of systolic blood pressure ≤98 mm Hg worked as the criterion of IAH. The activity of the ANS was evaluated by the I. Kérdö index.Results. It has been shown that women with IAH with sympathicotonia are characterized by a significant decrease in the structural parameters of the heart: the size of all chambers and the aortic ostium, contractile function decrease and a slower relaxation of the left ventricle (LV). Acceleration of intracardiac hemodynamics was observed: an increase in blood flow rates and pressure gradients on the mitral, tricuspid and pulmonary artery valves, an increase in the rates of early and late diastolic LV filling. Changes in early LV diastole are associated with an increase of pressure in the left atrium. We identified a restrictive type of diastolic dysfunction in women with parasympathicotonia.Conclusion. Sympathicotonia and parasympathicotonia in young women with IAH are associated with different heart remodeling variants. Cardiac hypotrophy, decrease of contractile function and impaired LV relaxation during hypotension are associated with low sympathetic activity against the background of parasympathicotonia. The restrictive type of diastolic dysfunction during hypotension is associated with parasympathicotonia. Use of cholinolytics and anticholinesterase reactivators are the potential way of correction of ANS dysfunction, IAH regression and cardiac remodeling.https://cardiovascular.elpub.ru/jour/article/view/812идиопатическая артериальная гипотензияремоделирование сердцаавтономная нервная система |
| spellingShingle | V. M. Baev Т. Yu. Agafonova Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women Кардиоваскулярная терапия и профилактика идиопатическая артериальная гипотензия ремоделирование сердца автономная нервная система |
| title | Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| title_full | Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| title_fullStr | Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| title_full_unstemmed | Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| title_short | Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| title_sort | pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women |
| topic | идиопатическая артериальная гипотензия ремоделирование сердца автономная нервная система |
| url | https://cardiovascular.elpub.ru/jour/article/view/812 |
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