Metformin and long non-coding RNAs in breast cancer
Abstract Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC risk, survival, clinical and pathological features. Recent studies also investigated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Translational Medicine |
| Online Access: | https://doi.org/10.1186/s12967-023-03909-x |
| _version_ | 1797863687313162240 |
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| author | Morteza Gholami Zeynab Nickhah Klashami Pirooz Ebrahimi Amir Ali Mahboobipour Amir Salehi Farid Aida Vahidi Marziyeh Zoughi Mojgan Asadi Mahsa M. Amoli |
| author_facet | Morteza Gholami Zeynab Nickhah Klashami Pirooz Ebrahimi Amir Ali Mahboobipour Amir Salehi Farid Aida Vahidi Marziyeh Zoughi Mojgan Asadi Mahsa M. Amoli |
| author_sort | Morteza Gholami |
| collection | DOAJ |
| description | Abstract Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC risk, survival, clinical and pathological features. Recent studies also investigated the roles of metformin treatment as the firstline treatment for type 2 diabetes (T2D) played in lncRNAs expression/regulation or BC incidence, outcome, mortality and survival, separately. This comprehensive study aimed to review lncRNAs associated with BC features and identify metformin-regulated lncRNAs and their mechanisms of action on BC or other types of cancers. Finally, metformin affects BC by regulating five BC-associated lncRNAs including GAS5, HOTAIR, MALAT1, and H19, by several molecular mechanisms have been described in this review. In addition, metformin action on other types of cancers by regulating ten lncRNAs including AC006160.1, Loc100506691, lncRNA-AF085935, SNHG7, HULC, UCA1, H19, MALAT1, AFAP1-AS1, AC026904.1 is described. |
| first_indexed | 2024-04-09T22:40:40Z |
| format | Article |
| id | doaj.art-9a05d094bbf943cf806420d040da48b0 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-09T22:40:40Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-9a05d094bbf943cf806420d040da48b02023-03-22T12:13:37ZengBMCJournal of Translational Medicine1479-58762023-02-0121112010.1186/s12967-023-03909-xMetformin and long non-coding RNAs in breast cancerMorteza Gholami0Zeynab Nickhah Klashami1Pirooz Ebrahimi2Amir Ali Mahboobipour3Amir Salehi Farid4Aida Vahidi5Marziyeh Zoughi6Mojgan Asadi7Mahsa M. Amoli8Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical SciencesMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical SciencesDepartment of Pharmacy, Health and Nutritional Sciences, University of CalabriaSchool of Medicine, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesMetabolomics and Genomics Research Center Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical SciencesMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical SciencesAbstract Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC risk, survival, clinical and pathological features. Recent studies also investigated the roles of metformin treatment as the firstline treatment for type 2 diabetes (T2D) played in lncRNAs expression/regulation or BC incidence, outcome, mortality and survival, separately. This comprehensive study aimed to review lncRNAs associated with BC features and identify metformin-regulated lncRNAs and their mechanisms of action on BC or other types of cancers. Finally, metformin affects BC by regulating five BC-associated lncRNAs including GAS5, HOTAIR, MALAT1, and H19, by several molecular mechanisms have been described in this review. In addition, metformin action on other types of cancers by regulating ten lncRNAs including AC006160.1, Loc100506691, lncRNA-AF085935, SNHG7, HULC, UCA1, H19, MALAT1, AFAP1-AS1, AC026904.1 is described.https://doi.org/10.1186/s12967-023-03909-x |
| spellingShingle | Morteza Gholami Zeynab Nickhah Klashami Pirooz Ebrahimi Amir Ali Mahboobipour Amir Salehi Farid Aida Vahidi Marziyeh Zoughi Mojgan Asadi Mahsa M. Amoli Metformin and long non-coding RNAs in breast cancer Journal of Translational Medicine |
| title | Metformin and long non-coding RNAs in breast cancer |
| title_full | Metformin and long non-coding RNAs in breast cancer |
| title_fullStr | Metformin and long non-coding RNAs in breast cancer |
| title_full_unstemmed | Metformin and long non-coding RNAs in breast cancer |
| title_short | Metformin and long non-coding RNAs in breast cancer |
| title_sort | metformin and long non coding rnas in breast cancer |
| url | https://doi.org/10.1186/s12967-023-03909-x |
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