Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure
The present study was undertaken to evaluate if any signifi cant hematological and biochemical changes occur in dogs with chronic heart failure (CHF), that will help in the diagnosis and prognosis of CHF. According to the obtained data, neutrophil leukocytosis was found in 22.2% of the animals in the...
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| Format: | Article |
| Language: | English |
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Bila Tserkva National Agrarian University
2020-05-01
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| Series: | Науковий вісник ветеринарної медицини |
| Subjects: | |
| Online Access: | http://nvvm.btsau.edu.ua/sites/all/modules/pubdlcnt/pubdlcnt.php?fid=1009 |
| _version_ | 1818645393891655680 |
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| author | Trofimjak R. L. Slivinska |
| author_facet | Trofimjak R. L. Slivinska |
| author_sort | Trofimjak R. |
| collection | DOAJ |
| description | The present study was undertaken to evaluate if any signifi cant hematological and biochemical changes occur in dogs with chronic heart failure (CHF), that will help in the diagnosis and prognosis of CHF. According to the obtained data, neutrophil leukocytosis was found in 22.2% of the animals in the experimental group, and anemia was found in 50.0%. Among them the 77,8 % of animals had nonregenerative anemia, the 77,8 % – hypochromic anemia, 38,9 % of – microcytic anemia. Neutrophil leukocytosis was registered in dogs with regenerative shift of the nucleus to the left (13.8%) and to the right (5.6%), and without changes in the leukogram (2.8%). It should be noted that 55.6% of animals with signs of CHF were also diagnosed with changes in the ratio of segmented neutrophils (degenerative shift of the nucleus to the left) in the absence of leukocytosis. Hypoproteinemia was found in 8,3% of animals, hypoalbuminemia in 13,8%, urea and creatinine concentrations were increased in 16,7 % and 19,4%, respectively. Hypocalcaemia was observed in 5,6% of dogs, inorganic phosphorus content was higher in 13,9%, slight hyponatremia was observed in 19,4%. The activity of enzymes in the serum of dogs in the experimental group ranged widely and was higher in ALT (p <0.001), AST (p <0.05), ALP (p <0.001), GGTP (p <0.01) compared with the control group.In the experimental group of 36 animals in 22,2 % of dogs were diagnosed cholestasis, in 22,2 % – hepatopathy, in 11,1 % – chronic kidney disease, and 8,3% –enteropathy, 5,5 % – paraneoplastic syndrome. Biochemical analysis of blood in dogs with signs of CHF is relevant, because it allows to diagnose comorbidities that may worsen the prognosis in these animals, and their timely detection and correction will increase the eff ectiveness of treatment. |
| first_indexed | 2024-12-17T00:30:02Z |
| format | Article |
| id | doaj.art-9a05e5adca7e43d6a84caed3434e0fbd |
| institution | Directory Open Access Journal |
| issn | 2310-4902 2415-7589 |
| language | English |
| last_indexed | 2024-12-17T00:30:02Z |
| publishDate | 2020-05-01 |
| publisher | Bila Tserkva National Agrarian University |
| record_format | Article |
| series | Науковий вісник ветеринарної медицини |
| spelling | doaj.art-9a05e5adca7e43d6a84caed3434e0fbd2022-12-21T22:10:21ZengBila Tserkva National Agrarian UniversityНауковий вісник ветеринарної медицини2310-49022415-75892020-05-011637110.33245/2310-4902-2020-154-1-63-71Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failureTrofimjak R.0https://orcid.org/0000-0003-2780-3682 L. Slivinska1https://orcid.org/0000-0003-4441-7628Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies LvivStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies LvivThe present study was undertaken to evaluate if any signifi cant hematological and biochemical changes occur in dogs with chronic heart failure (CHF), that will help in the diagnosis and prognosis of CHF. According to the obtained data, neutrophil leukocytosis was found in 22.2% of the animals in the experimental group, and anemia was found in 50.0%. Among them the 77,8 % of animals had nonregenerative anemia, the 77,8 % – hypochromic anemia, 38,9 % of – microcytic anemia. Neutrophil leukocytosis was registered in dogs with regenerative shift of the nucleus to the left (13.8%) and to the right (5.6%), and without changes in the leukogram (2.8%). It should be noted that 55.6% of animals with signs of CHF were also diagnosed with changes in the ratio of segmented neutrophils (degenerative shift of the nucleus to the left) in the absence of leukocytosis. Hypoproteinemia was found in 8,3% of animals, hypoalbuminemia in 13,8%, urea and creatinine concentrations were increased in 16,7 % and 19,4%, respectively. Hypocalcaemia was observed in 5,6% of dogs, inorganic phosphorus content was higher in 13,9%, slight hyponatremia was observed in 19,4%. The activity of enzymes in the serum of dogs in the experimental group ranged widely and was higher in ALT (p <0.001), AST (p <0.05), ALP (p <0.001), GGTP (p <0.01) compared with the control group.In the experimental group of 36 animals in 22,2 % of dogs were diagnosed cholestasis, in 22,2 % – hepatopathy, in 11,1 % – chronic kidney disease, and 8,3% –enteropathy, 5,5 % – paraneoplastic syndrome. Biochemical analysis of blood in dogs with signs of CHF is relevant, because it allows to diagnose comorbidities that may worsen the prognosis in these animals, and their timely detection and correction will increase the eff ectiveness of treatment.http://nvvm.btsau.edu.ua/sites/all/modules/pubdlcnt/pubdlcnt.php?fid=1009chronic heart failuredoghematology analysisanemialeukocytosishypoalbuminemiarenal failurecholestasishepatopathy |
| spellingShingle | Trofimjak R. L. Slivinska Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure Науковий вісник ветеринарної медицини chronic heart failure dog hematology analysis anemia leukocytosis hypoalbuminemia renal failure cholestasis hepatopathy |
| title | Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure |
| title_full | Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure |
| title_fullStr | Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure |
| title_full_unstemmed | Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure |
| title_short | Hematopoiesis and biochemical profi les of dogs' blood by chronic heart failure |
| title_sort | hematopoiesis and biochemical profi les of dogs blood by chronic heart failure |
| topic | chronic heart failure dog hematology analysis anemia leukocytosis hypoalbuminemia renal failure cholestasis hepatopathy |
| url | http://nvvm.btsau.edu.ua/sites/all/modules/pubdlcnt/pubdlcnt.php?fid=1009 |
| work_keys_str_mv | AT trofimjakr hematopoiesisandbiochemicalprofilesofdogsbloodbychronicheartfailure AT lslivinska hematopoiesisandbiochemicalprofilesofdogsbloodbychronicheartfailure |