The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study
Gliomas disturb brain functions, contributing to abnormal neuronal activity and connectivity changes that can be effectively investigated using magnetoencephalography (MEG). In this work, we used MEG to evaluate frequency-specific alterations of brain activity and functional connectivity in glioma p...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Neuroimage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956021000490 |
| _version_ | 1818995384035311616 |
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| author | Fatemeh Shekoohishooli Federico Chella Massimo Caulo Riccardo Navarra Matteo Rapino Vittorio Pizzella Laura Marzetti |
| author_facet | Fatemeh Shekoohishooli Federico Chella Massimo Caulo Riccardo Navarra Matteo Rapino Vittorio Pizzella Laura Marzetti |
| author_sort | Fatemeh Shekoohishooli |
| collection | DOAJ |
| description | Gliomas disturb brain functions, contributing to abnormal neuronal activity and connectivity changes that can be effectively investigated using magnetoencephalography (MEG). In this work, we used MEG to evaluate frequency-specific alterations of brain activity and functional connectivity in glioma patients. Two consecutive 5-min sessions of eyes-closed resting-state brain activity were recorded from ten glioma patients and ten age-matched healthy subjects. Modulations of power and functional connectivity, within the patient group and between patients and the healthy control group, were assessed in terms of the Neural Activity Index and the Multivariate Interaction Measure, respectively. These quantities were calculated in individualized frequency bands (delta, theta, lower alpha, upper alpha and beta) to account for changes in spectral peaks in patients.We report a decrease in power in tumor and peri-tumor regions in the upper-alpha and beta bands with respect to the rest of the brain, paired to a decrease in lower and upper-alpha band functional connectivity of the tumor and peri-tumor regions. In comparison with healthy subjects, we observe a global enhancement in power in lower-alpha in patients.Overall, our study shows that glioma infiltration can widely influence brain local and long-range synchrony in an individualized frequency-specific manner. |
| first_indexed | 2024-12-20T21:12:59Z |
| format | Article |
| id | doaj.art-9a0acb21388c4e27b1bbee588fb5f52e |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-12-20T21:12:59Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-9a0acb21388c4e27b1bbee588fb5f52e2022-12-21T19:26:29ZengElsevierNeuroimage: Reports2666-95602021-12-0114100051The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography studyFatemeh Shekoohishooli0Federico Chella1Massimo Caulo2Riccardo Navarra3Matteo Rapino4Vittorio Pizzella5Laura Marzetti6Department of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, Italy; Institute for Advanced Biomedical Technologies, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, Italy; Institute for Advanced Biomedical Technologies, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Sciences, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, Italy; Institute for Advanced Biomedical Technologies, “G. d'Annunzio University” of Chieti-Pescara, 66100, Chieti, Italy; Corresponding author. Institute for Advanced Biomedical Technologies, ''G. d'Annunzio University” of Chieti-Pescara, via Luigi Polacchi 11, 66100, Chieti, Italy.Gliomas disturb brain functions, contributing to abnormal neuronal activity and connectivity changes that can be effectively investigated using magnetoencephalography (MEG). In this work, we used MEG to evaluate frequency-specific alterations of brain activity and functional connectivity in glioma patients. Two consecutive 5-min sessions of eyes-closed resting-state brain activity were recorded from ten glioma patients and ten age-matched healthy subjects. Modulations of power and functional connectivity, within the patient group and between patients and the healthy control group, were assessed in terms of the Neural Activity Index and the Multivariate Interaction Measure, respectively. These quantities were calculated in individualized frequency bands (delta, theta, lower alpha, upper alpha and beta) to account for changes in spectral peaks in patients.We report a decrease in power in tumor and peri-tumor regions in the upper-alpha and beta bands with respect to the rest of the brain, paired to a decrease in lower and upper-alpha band functional connectivity of the tumor and peri-tumor regions. In comparison with healthy subjects, we observe a global enhancement in power in lower-alpha in patients.Overall, our study shows that glioma infiltration can widely influence brain local and long-range synchrony in an individualized frequency-specific manner.http://www.sciencedirect.com/science/article/pii/S2666956021000490Glioma patientsResting-stateMagnetoencephalographyFunctional connectivity |
| spellingShingle | Fatemeh Shekoohishooli Federico Chella Massimo Caulo Riccardo Navarra Matteo Rapino Vittorio Pizzella Laura Marzetti The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study Neuroimage: Reports Glioma patients Resting-state Magnetoencephalography Functional connectivity |
| title | The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study |
| title_full | The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study |
| title_fullStr | The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study |
| title_full_unstemmed | The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study |
| title_short | The impact of gliomas on resting-state oscillatory activity and connectivity: A magnetoencephalography study |
| title_sort | impact of gliomas on resting state oscillatory activity and connectivity a magnetoencephalography study |
| topic | Glioma patients Resting-state Magnetoencephalography Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S2666956021000490 |
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