Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

Tumor-associated macrophages (TAMs) generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis, suggesting their potential value as a target in cancer immunotherapy. Chlorogenic acid (CHA) has been identified as a potent immunomodulator that promotes the polariz...

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Bibliographic Details
Main Authors: Jun Ye, Yanfang Yang, Jing Jin, Ming Ji, Yue Gao, Yu Feng, Hongliang Wang, Xiaoguang Chen, Yuling Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-09-01
Series:Bioactive Materials
Subjects:
Chlorogenic acid
Mannosylated liposome
Tumor-associated macrophage
Cancer immunotherapy
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20300839

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