Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility

In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO...

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Main Authors: Yifan Liu, Zhengqi Liu, Ya Gao, Weiwei Gao, Zhaosheng Hou, Yuzheng Zhu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Membranes
Subjects:
Online Access:https://www.mdpi.com/2077-0375/11/1/37
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author Yifan Liu
Zhengqi Liu
Ya Gao
Weiwei Gao
Zhaosheng Hou
Yuzheng Zhu
author_facet Yifan Liu
Zhengqi Liu
Ya Gao
Weiwei Gao
Zhaosheng Hou
Yuzheng Zhu
author_sort Yifan Liu
collection DOAJ
description In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO groups were first introduced on the surface with high grafting density, which were then coupled with -NH<sub>2</sub> groups of CHO to immobilize CHO on the SPU surface (SPU-CHO). The CHO-covered surface was characterized by FT-IR and water contact angle test. Due to the hydrophilicity of CHO, the SPU-CHO possessed higher surface hydrophilicity and faster hydrolytic degradation rate than blank SPU. The almost overlapping stress-strain curves of SPU and SPU-CHO films demonstrated that the chemical treatments had little destruction on the intrinsic properties of the substrate. In addition, the significant inhibition of platelet adhesion and protein adsorption on CHO-covered surface endowed SPU-CHO an outstanding surface biocompatibility (especially blood compatibility). These results indicated that the CHO-grafted SPU was a promising candidate as blood-contacting biomaterial for biomedical applications.
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spelling doaj.art-9a0e0a69bc774120ac2dbcd9b27a2a502023-11-21T08:12:11ZengMDPI AGMembranes2077-03752021-01-011113710.3390/membranes11010037Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface BiocompatibilityYifan Liu0Zhengqi Liu1Ya Gao2Weiwei Gao3Zhaosheng Hou4Yuzheng Zhu5College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, ChinaSagacis Biotechnology Co., Ltd., Jinan 250101, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, ChinaShandong Tianming Pharmaceutical Co., Ltd., Jinan 250100, ChinaIn the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO groups were first introduced on the surface with high grafting density, which were then coupled with -NH<sub>2</sub> groups of CHO to immobilize CHO on the SPU surface (SPU-CHO). The CHO-covered surface was characterized by FT-IR and water contact angle test. Due to the hydrophilicity of CHO, the SPU-CHO possessed higher surface hydrophilicity and faster hydrolytic degradation rate than blank SPU. The almost overlapping stress-strain curves of SPU and SPU-CHO films demonstrated that the chemical treatments had little destruction on the intrinsic properties of the substrate. In addition, the significant inhibition of platelet adhesion and protein adsorption on CHO-covered surface endowed SPU-CHO an outstanding surface biocompatibility (especially blood compatibility). These results indicated that the CHO-grafted SPU was a promising candidate as blood-contacting biomaterial for biomedical applications.https://www.mdpi.com/2077-0375/11/1/37segmented poly(ester-urethane)chitooligosaccharidesurface graftingbiocompatibility
spellingShingle Yifan Liu
Zhengqi Liu
Ya Gao
Weiwei Gao
Zhaosheng Hou
Yuzheng Zhu
Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
Membranes
segmented poly(ester-urethane)
chitooligosaccharide
surface grafting
biocompatibility
title Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
title_full Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
title_fullStr Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
title_full_unstemmed Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
title_short Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility
title_sort facile method for surface grafted chitooligosaccharide on medical segmented poly ester urethane film to improve surface biocompatibility
topic segmented poly(ester-urethane)
chitooligosaccharide
surface grafting
biocompatibility
url https://www.mdpi.com/2077-0375/11/1/37
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