Identifying individual T cell receptors of optimal avidity for tumor antigens

Identifying individual T cell receptors of optimal avidity for tumor antigens

Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented by the Major Histocompatibility Complex (pMHC) on the surface of professional antigen presenting cells (APC), and infected or malignant cells. The efficiency of T cell triggering critically depends on...

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Bibliographic Details
Main Authors: Michaël eHebeisen, Mathilde eAllard, Philippe eGannon, Julien eSchmidt, Daniel Ernst Speiser, Nathalie eRufer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
Melanoma
Cytotoxic T Cells
TCR repertoire
Tumor antigens
TCR Affinity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00582/full

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