Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model.

Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model.

Tay-Sachs disease is a lethal lysosomal storage disorder caused by mutations in the HexA gene encoding the α subunit of the lysosomal β-hexosaminidase enzyme (HEXA). Abnormal GM2 ganglioside accumulation causes progressive deterioration in the central nervous system in Tay-Sachs patients. Hexa-/- mo...

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Bibliographic Details
Main Authors:	Tugce Sengul, Melike Can, Nurselin Ateş, Volkan Seyrantepe
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0280650

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