Global, local and focused geographic clustering for case-control data with residential histories
<p>Abstract</p> <p>Background</p> <p>This paper introduces a new approach for evaluating clustering in case-control data that accounts for residential histories. Although many statistics have been proposed for assessing local, focused and global clustering in health out...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-03-01
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| Series: | Environmental Health |
| Online Access: | http://www.ehjournal.net/content/4/1/4 |
| _version_ | 1818756396573786112 |
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| author | AvRuskin Gillian Goovaerts Pierre Meliker Jaymie Kaufmann Andy Jacquez Geoffrey M Nriagu Jerome |
| author_facet | AvRuskin Gillian Goovaerts Pierre Meliker Jaymie Kaufmann Andy Jacquez Geoffrey M Nriagu Jerome |
| author_sort | AvRuskin Gillian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This paper introduces a new approach for evaluating clustering in case-control data that accounts for residential histories. Although many statistics have been proposed for assessing local, focused and global clustering in health outcomes, few, if any, exist for evaluating clusters when individuals are mobile.</p> <p>Methods</p> <p>Local, global and focused tests for residential histories are developed based on sets of matrices of nearest neighbor relationships that reflect the changing topology of cases and controls. Exposure traces are defined that account for the latency between exposure and disease manifestation, and that use exposure windows whose duration may vary. Several of the methods so derived are applied to evaluate clustering of residential histories in a case-control study of bladder cancer in south eastern Michigan. These data are still being collected and the analysis is conducted for demonstration purposes only.</p> <p>Results</p> <p>Statistically significant clustering of residential histories of cases was found but is likely due to delayed reporting of cases by one of the hospitals participating in the study.</p> <p>Conclusion</p> <p>Data with residential histories are preferable when causative exposures and disease latencies occur on a long enough time span that human mobility matters. To analyze such data, methods are needed that take residential histories into account.</p> |
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| format | Article |
| id | doaj.art-9a11476f11644044b99c8ecd0b6df78c |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-18T05:54:23Z |
| publishDate | 2005-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-9a11476f11644044b99c8ecd0b6df78c2022-12-21T21:18:50ZengBMCEnvironmental Health1476-069X2005-03-0141410.1186/1476-069X-4-4Global, local and focused geographic clustering for case-control data with residential historiesAvRuskin GillianGoovaerts PierreMeliker JaymieKaufmann AndyJacquez Geoffrey MNriagu Jerome<p>Abstract</p> <p>Background</p> <p>This paper introduces a new approach for evaluating clustering in case-control data that accounts for residential histories. Although many statistics have been proposed for assessing local, focused and global clustering in health outcomes, few, if any, exist for evaluating clusters when individuals are mobile.</p> <p>Methods</p> <p>Local, global and focused tests for residential histories are developed based on sets of matrices of nearest neighbor relationships that reflect the changing topology of cases and controls. Exposure traces are defined that account for the latency between exposure and disease manifestation, and that use exposure windows whose duration may vary. Several of the methods so derived are applied to evaluate clustering of residential histories in a case-control study of bladder cancer in south eastern Michigan. These data are still being collected and the analysis is conducted for demonstration purposes only.</p> <p>Results</p> <p>Statistically significant clustering of residential histories of cases was found but is likely due to delayed reporting of cases by one of the hospitals participating in the study.</p> <p>Conclusion</p> <p>Data with residential histories are preferable when causative exposures and disease latencies occur on a long enough time span that human mobility matters. To analyze such data, methods are needed that take residential histories into account.</p>http://www.ehjournal.net/content/4/1/4 |
| spellingShingle | AvRuskin Gillian Goovaerts Pierre Meliker Jaymie Kaufmann Andy Jacquez Geoffrey M Nriagu Jerome Global, local and focused geographic clustering for case-control data with residential histories Environmental Health |
| title | Global, local and focused geographic clustering for case-control data with residential histories |
| title_full | Global, local and focused geographic clustering for case-control data with residential histories |
| title_fullStr | Global, local and focused geographic clustering for case-control data with residential histories |
| title_full_unstemmed | Global, local and focused geographic clustering for case-control data with residential histories |
| title_short | Global, local and focused geographic clustering for case-control data with residential histories |
| title_sort | global local and focused geographic clustering for case control data with residential histories |
| url | http://www.ehjournal.net/content/4/1/4 |
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