Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma
Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM is a multistep process based on genomic instability, epigenetic dysregulation and a tight cross-talk with the BM microenvironment tha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/15448 |
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| author | Nicolas Thomas Iannozzi Valentina Marchica Denise Toscani Jessica Burroughs Garcìa Nicola Giuliani Paola Storti |
| author_facet | Nicolas Thomas Iannozzi Valentina Marchica Denise Toscani Jessica Burroughs Garcìa Nicola Giuliani Paola Storti |
| author_sort | Nicolas Thomas Iannozzi |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM is a multistep process based on genomic instability, epigenetic dysregulation and a tight cross-talk with the BM microenvironment that plays a pivotal role supporting the proliferation, survival, drug-resistance and homing of PCs. The BM microenvironment consists of a hematopoietic and a non-hematopoietic compartment, which cooperate to create a tumor environment. Among the non-hematopoietic component, mesenchymal stromal cells (MSCs) and osteoblasts (OBs) appear transcriptionally and functionally different in MM patients compared to healthy donors (HDs) and to patients with pre-malignant monoclonal gammopathies. Alterations of both MSCs and OBs underly the osteolytic lesions that characterize myeloma-associated bone disease. In this review, we will discuss the different characteristics of MSCs and OBs in MM patients, analyzing the transcriptome, the deregulated molecular pathways and the role performed by miRNAs and exosome in the pathophysiology of MM. |
| first_indexed | 2024-03-09T16:20:53Z |
| format | Article |
| id | doaj.art-9a16cead0a2a41ba8570802ef8945709 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:20:53Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a16cead0a2a41ba8570802ef89457092023-11-24T15:21:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241544810.3390/ijms232415448Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple MyelomaNicolas Thomas Iannozzi0Valentina Marchica1Denise Toscani2Jessica Burroughs Garcìa3Nicola Giuliani4Paola Storti5Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyHematology, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyMultiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM is a multistep process based on genomic instability, epigenetic dysregulation and a tight cross-talk with the BM microenvironment that plays a pivotal role supporting the proliferation, survival, drug-resistance and homing of PCs. The BM microenvironment consists of a hematopoietic and a non-hematopoietic compartment, which cooperate to create a tumor environment. Among the non-hematopoietic component, mesenchymal stromal cells (MSCs) and osteoblasts (OBs) appear transcriptionally and functionally different in MM patients compared to healthy donors (HDs) and to patients with pre-malignant monoclonal gammopathies. Alterations of both MSCs and OBs underly the osteolytic lesions that characterize myeloma-associated bone disease. In this review, we will discuss the different characteristics of MSCs and OBs in MM patients, analyzing the transcriptome, the deregulated molecular pathways and the role performed by miRNAs and exosome in the pathophysiology of MM.https://www.mdpi.com/1422-0067/23/24/15448multiple myelomamesenchymal cellsosteoblastsmolecular pathways |
| spellingShingle | Nicolas Thomas Iannozzi Valentina Marchica Denise Toscani Jessica Burroughs Garcìa Nicola Giuliani Paola Storti Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma International Journal of Molecular Sciences multiple myeloma mesenchymal cells osteoblasts molecular pathways |
| title | Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma |
| title_full | Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma |
| title_fullStr | Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma |
| title_full_unstemmed | Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma |
| title_short | Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma |
| title_sort | molecular features of the mesenchymal and osteoblastic cells in multiple myeloma |
| topic | multiple myeloma mesenchymal cells osteoblasts molecular pathways |
| url | https://www.mdpi.com/1422-0067/23/24/15448 |
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