2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow
Many diseases are related to cerebrospinal .uid (CSF) hydrodynamics. Therefore, understanding the hydrodynamics of CSF .ow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. Furthermore, engineering a reliable computational...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2013-02-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-145&slc_lang=en&sid=1 |
| _version_ | 1797280526723186688 |
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| author | Nafiseh Masoumi F. Framanzad Behnam Zamanian A.S. Seddighi M.H. Moosavi S. Najarian Dariush Bastani |
| author_facet | Nafiseh Masoumi F. Framanzad Behnam Zamanian A.S. Seddighi M.H. Moosavi S. Najarian Dariush Bastani |
| author_sort | Nafiseh Masoumi |
| collection | DOAJ |
| description | Many diseases are related to cerebrospinal .uid (CSF) hydrodynamics. Therefore, understanding the hydrodynamics of CSF .ow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. Furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing generic medicines.
A Fluid-Solid Interaction (FSI)model was constructed to simulate CSF .ow. An important problem in modeling the CSF .ow is the diastolic back .ow. In this article, using both rigid and .exible conditions for ventricular system allowed us to evaluate the effect of surrounding brain tissue. Our model assumed an elastic wall for the ventricles and a pulsatile CSF input as its boundary conditions. A comparison of the results and the experimental data was done. The .exible model gave better results because it could reproduce the diastolic back .ow mentioned in clinical research studies. The previous rigid models have ignored the brain parenchyma interaction with CSF and so had not reported the back .ow during the diastolic time. In this computational .uid dynamic (CFD) analysis, the CSF pressure and .ow velocity in different areas were concordant with the experimental data. |
| first_indexed | 2024-03-07T16:42:26Z |
| format | Article |
| id | doaj.art-9a179264730942b08b6c6c8ca3d09833 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:42:26Z |
| publishDate | 2013-02-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-9a179264730942b08b6c6c8ca3d098332024-03-03T07:47:27ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422013-02-014164752D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile FlowNafiseh Masoumi0F. Framanzad1Behnam Zamanian2A.S. Seddighi3M.H. Moosavi4S. Najarian5Dariush Bastani6 Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran. Biomechanics Group Faculty, Mechanical Engineering Department, Iranian University of Science and Technology, Tehran, Iran. Department of Chemical Engineering, North Eastern University, Boston, MA,USA. Neurosurgery Department, Shohada-e-Tajrish Hospital, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Faculty of Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran. Many diseases are related to cerebrospinal .uid (CSF) hydrodynamics. Therefore, understanding the hydrodynamics of CSF .ow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. Furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing generic medicines. A Fluid-Solid Interaction (FSI)model was constructed to simulate CSF .ow. An important problem in modeling the CSF .ow is the diastolic back .ow. In this article, using both rigid and .exible conditions for ventricular system allowed us to evaluate the effect of surrounding brain tissue. Our model assumed an elastic wall for the ventricles and a pulsatile CSF input as its boundary conditions. A comparison of the results and the experimental data was done. The .exible model gave better results because it could reproduce the diastolic back .ow mentioned in clinical research studies. The previous rigid models have ignored the brain parenchyma interaction with CSF and so had not reported the back .ow during the diastolic time. In this computational .uid dynamic (CFD) analysis, the CSF pressure and .ow velocity in different areas were concordant with the experimental data.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-145&slc_lang=en&sid=1Cerebrospinal FluidFSI modeling PulsatileHydrodynamics Computational Fluid Dynamics (CFD) |
| spellingShingle | Nafiseh Masoumi F. Framanzad Behnam Zamanian A.S. Seddighi M.H. Moosavi S. Najarian Dariush Bastani 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow Basic and Clinical Neuroscience Cerebrospinal Fluid FSI modeling Pulsatile Hydrodynamics Computational Fluid Dynamics (CFD) |
| title | 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow |
| title_full | 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow |
| title_fullStr | 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow |
| title_full_unstemmed | 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow |
| title_short | 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow |
| title_sort | 2d computational fluid dynamic modeling of human ventricle system based on fluid solid interaction and pulsatile flow |
| topic | Cerebrospinal Fluid FSI modeling Pulsatile Hydrodynamics Computational Fluid Dynamics (CFD) |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-145&slc_lang=en&sid=1 |
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