Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial
ABSTRACT INTRODUCTION: Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxici...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200203&lng=en&tlng=en |
| _version_ | 1818447680179798016 |
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| author | Fábio Coelho Alves Silveira Flávia Cristina Morone Pinto Sílvio da Silva Caldas Neto Mariana de Carvalho Leal Jéssica Cesário José Lamartine de Andrade Aguiar |
| author_facet | Fábio Coelho Alves Silveira Flávia Cristina Morone Pinto Sílvio da Silva Caldas Neto Mariana de Carvalho Leal Jéssica Cesário José Lamartine de Andrade Aguiar |
| author_sort | Fábio Coelho Alves Silveira |
| collection | DOAJ |
| description | ABSTRACT INTRODUCTION: Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxicity. OBJECTIVES: To investigate the effect on healing of direct application of a bacterial cellulose graft on the tympanic membrane compared to the conventional approach with autologous fascia. METHODS: Randomized controlled trial. Forty patients with tympanic membrane perforations secondary to chronic otitis media were included, and were randomly assigned to an experimental group (20), treated with a bacterial cellulose graft (BC) and control group (20), treated with autologous temporal fascia (fascia). We evaluated the surgical time, hospital stay, time of epithelialization and the rate of tympanic perforation closure. Hospital costs were compared. The statistical significance level accepted was established at p < 0.05. RESULTS: The closure of perforations was similar in both groups. The average operation time in the fascia group was 76.50 min versus 14.06 min bacterial cellulose in the group (p = 0.0001). The hospital cost by the Brazilian public health system was R$ 600.00 for the bacterial cellulose group, and R$ 7778.00 for the fascia group (p = 0.0001). CONCLUSION: Bacterial cellulose grafts promoted the closure of the tympanic membrane perforations, and were demonstrated to be innovative, effective, safe, minimally invasive, efficacious and to have a very low cost. |
| first_indexed | 2024-12-14T20:07:28Z |
| format | Article |
| id | doaj.art-9a18366ff21e46c38c644fcef38e656b |
| institution | Directory Open Access Journal |
| issn | 1808-8686 |
| language | English |
| last_indexed | 2024-12-14T20:07:28Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-9a18366ff21e46c38c644fcef38e656b2022-12-21T22:49:01ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86862016-04-0182220320810.1016/j.bjorl.2015.03.015S1808-86942016000200203Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trialFábio Coelho Alves SilveiraFlávia Cristina Morone PintoSílvio da Silva Caldas NetoMariana de Carvalho LealJéssica CesárioJosé Lamartine de Andrade AguiarABSTRACT INTRODUCTION: Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxicity. OBJECTIVES: To investigate the effect on healing of direct application of a bacterial cellulose graft on the tympanic membrane compared to the conventional approach with autologous fascia. METHODS: Randomized controlled trial. Forty patients with tympanic membrane perforations secondary to chronic otitis media were included, and were randomly assigned to an experimental group (20), treated with a bacterial cellulose graft (BC) and control group (20), treated with autologous temporal fascia (fascia). We evaluated the surgical time, hospital stay, time of epithelialization and the rate of tympanic perforation closure. Hospital costs were compared. The statistical significance level accepted was established at p < 0.05. RESULTS: The closure of perforations was similar in both groups. The average operation time in the fascia group was 76.50 min versus 14.06 min bacterial cellulose in the group (p = 0.0001). The hospital cost by the Brazilian public health system was R$ 600.00 for the bacterial cellulose group, and R$ 7778.00 for the fascia group (p = 0.0001). CONCLUSION: Bacterial cellulose grafts promoted the closure of the tympanic membrane perforations, and were demonstrated to be innovative, effective, safe, minimally invasive, efficacious and to have a very low cost.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200203&lng=en&tlng=enPerfuração da membrana timpânicaBiopolímeroCelulose bacteriana |
| spellingShingle | Fábio Coelho Alves Silveira Flávia Cristina Morone Pinto Sílvio da Silva Caldas Neto Mariana de Carvalho Leal Jéssica Cesário José Lamartine de Andrade Aguiar Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial Brazilian Journal of Otorhinolaryngology Perfuração da membrana timpânica Biopolímero Celulose bacteriana |
| title | Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial |
| title_full | Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial |
| title_fullStr | Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial |
| title_full_unstemmed | Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial |
| title_short | Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial |
| title_sort | treatment of tympanic membrane perforation using bacterial cellulose a randomized controlled trial |
| topic | Perfuração da membrana timpânica Biopolímero Celulose bacteriana |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200203&lng=en&tlng=en |
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