Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men
Background: Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the rat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Metabolism Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258993682300021X |
| _version_ | 1797800987948220416 |
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| author | Holiness Stephen Adedeji Olasore Tolulope Adejoke Oyedeji Matthew Olamide Olawale Omobolanle Ibukun Ogundele Joseph Ogo-Oluwa Faleti |
| author_facet | Holiness Stephen Adedeji Olasore Tolulope Adejoke Oyedeji Matthew Olamide Olawale Omobolanle Ibukun Ogundele Joseph Ogo-Oluwa Faleti |
| author_sort | Holiness Stephen Adedeji Olasore |
| collection | DOAJ |
| description | Background: Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men. Method: Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software. Results: Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, <0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively). Conclusion: These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides. |
| first_indexed | 2024-03-13T04:43:34Z |
| format | Article |
| id | doaj.art-9a18856999c440a5986fdc88284190b7 |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-03-13T04:43:34Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-9a18856999c440a5986fdc88284190b72023-06-19T04:29:23ZengElsevierMetabolism Open2589-93682023-06-0118100249Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian menHoliness Stephen Adedeji Olasore0Tolulope Adejoke Oyedeji1Matthew Olamide Olawale2Omobolanle Ibukun Ogundele3Joseph Ogo-Oluwa Faleti4Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria; Corresponding author. Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, PMB 12003, Idi Araba, Lagos, Nigeria.Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, Idi Araba, Lagos, NigeriaDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, Idi Araba, Lagos, NigeriaDepartment of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Idi Araba Campus, Lagos, NigeriaDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, Idi Araba, Lagos, NigeriaBackground: Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men. Method: Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software. Results: Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, <0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively). Conclusion: These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides.http://www.sciencedirect.com/science/article/pii/S258993682300021XTestosteroneEstradiolWeightHeightBody mass indexFasting blood glucose |
| spellingShingle | Holiness Stephen Adedeji Olasore Tolulope Adejoke Oyedeji Matthew Olamide Olawale Omobolanle Ibukun Ogundele Joseph Ogo-Oluwa Faleti Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men Metabolism Open Testosterone Estradiol Weight Height Body mass index Fasting blood glucose |
| title | Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men |
| title_full | Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men |
| title_fullStr | Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men |
| title_full_unstemmed | Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men |
| title_short | Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men |
| title_sort | relationship between testosterone estradiol ratio and some anthropometric and metabolic parameters among nigerian men |
| topic | Testosterone Estradiol Weight Height Body mass index Fasting blood glucose |
| url | http://www.sciencedirect.com/science/article/pii/S258993682300021X |
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