MHCII expression on gut macrophages supports T cell homeostasis and is regulated by microbiota and ontogeny

Abstract Macrophages are traditionally considered antigen-presenting cells. However, their ability to present antigen and the factors regulating macrophage MHCII expression are poorly understood. Here, we demonstrate that MHCII expression on murine intestinal macrophages is differentially controlled...

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Bibliographic Details
Main Authors: Joël Guillaume, Andrea Leufgen, Fabian T. Hager, Oliver Pabst, Vuk Cerovic
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28554-8