Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population
Purpose: Our aim was to determine a more predictive cut-off value for free to total prostate-specific antigen ratio (f/tPSA) to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) in Iranian patients with serum PSA levels between 4 and 20 ng/mL.Materials and Methods: Th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
2010-05-01
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| Series: | Urology Journal |
| Subjects: | |
| Online Access: | http://urologyjournal.org/index.php/uj/article/view/675/467 |
| _version_ | 1818806743990272000 |
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| author | Khosro Rahbar Mohammadtaha Jalali Nasser Kamalian Javad Sanadizade Mohammad Sanadizade Faranak Kazerouni Houshang Amirrasouli Kamran Karimi |
| author_facet | Khosro Rahbar Mohammadtaha Jalali Nasser Kamalian Javad Sanadizade Mohammad Sanadizade Faranak Kazerouni Houshang Amirrasouli Kamran Karimi |
| author_sort | Khosro Rahbar |
| collection | DOAJ |
| description | Purpose: Our aim was to determine a more predictive cut-off value for free to total prostate-specific antigen ratio (f/tPSA) to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) in Iranian patients with serum PSA levels between 4 and 20 ng/mL.Materials and Methods: This study was performed on 332 men with serum tPSA level of 4 to 20 ng/mL. All patients underwent transrectal ultrasound guided biopsies. Serum levels of tPSA and fPSA were measured by Roche immunoassay Elecsys 2010. Relationship between f/tPSA and cases of PCawas determined.Results: Prostate cancer detected in 49 (15%) patients. Incidence of PCa for serum tPSA level < 10ng/mL and serum tPSA level of 10.1 to 20 ng/ mL was 17 (6.7%) and 32 (39.5%), respectively. Mean f/tPSA value was significantly lower in PCa patients (0.12 ± 0.01) than in benign histology group (0.16 ± 0.03). Among patients with serum PSA level of 4 to 10 ng/mL (n = 251), mean f/tPSA in benign histology group (n = 234) was 0.16 ± 0.08 and in PCa group (n = 17) was 0.13 ± 0.06 (P < .05). For serum PSA level of 10.1 to 20 ng/mL (n = 81), mean f/tPSA in benign histology group (n = 49) was 0.16 ± 0.08 and in PCa group (n = 32) was 0.12 ± 0.05 (P < .05). The cut-off value of 0.12 produced 76% sensitivity and 71 % specificity, whereas the cut-off value of 0.14 yielded 83.5 % sensitivity and 61% specificity.Conclusion: Determination of f/tPSA ratio improves differentiation of Pca from BPH. We recommend a cut-off value of 0.14 to be applied to Iranian patients. |
| first_indexed | 2024-12-18T19:14:38Z |
| format | Article |
| id | doaj.art-9a1a6792487e4f6e9e2b5a816803fa4d |
| institution | Directory Open Access Journal |
| issn | 1735-1308 1735-546X |
| language | English |
| last_indexed | 2024-12-18T19:14:38Z |
| publishDate | 2010-05-01 |
| publisher | Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Urology Journal |
| spelling | doaj.art-9a1a6792487e4f6e9e2b5a816803fa4d2022-12-21T20:56:10ZengUrology and Nephrology Research Center, Shahid Beheshti University of Medical SciencesUrology Journal1735-13081735-546X2010-05-017299104Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian PopulationKhosro RahbarMohammadtaha JalaliNasser KamalianJavad SanadizadeMohammad SanadizadeFaranak KazerouniHoushang AmirrasouliKamran KarimiPurpose: Our aim was to determine a more predictive cut-off value for free to total prostate-specific antigen ratio (f/tPSA) to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) in Iranian patients with serum PSA levels between 4 and 20 ng/mL.Materials and Methods: This study was performed on 332 men with serum tPSA level of 4 to 20 ng/mL. All patients underwent transrectal ultrasound guided biopsies. Serum levels of tPSA and fPSA were measured by Roche immunoassay Elecsys 2010. Relationship between f/tPSA and cases of PCawas determined.Results: Prostate cancer detected in 49 (15%) patients. Incidence of PCa for serum tPSA level < 10ng/mL and serum tPSA level of 10.1 to 20 ng/ mL was 17 (6.7%) and 32 (39.5%), respectively. Mean f/tPSA value was significantly lower in PCa patients (0.12 ± 0.01) than in benign histology group (0.16 ± 0.03). Among patients with serum PSA level of 4 to 10 ng/mL (n = 251), mean f/tPSA in benign histology group (n = 234) was 0.16 ± 0.08 and in PCa group (n = 17) was 0.13 ± 0.06 (P < .05). For serum PSA level of 10.1 to 20 ng/mL (n = 81), mean f/tPSA in benign histology group (n = 49) was 0.16 ± 0.08 and in PCa group (n = 32) was 0.12 ± 0.05 (P < .05). The cut-off value of 0.12 produced 76% sensitivity and 71 % specificity, whereas the cut-off value of 0.14 yielded 83.5 % sensitivity and 61% specificity.Conclusion: Determination of f/tPSA ratio improves differentiation of Pca from BPH. We recommend a cut-off value of 0.14 to be applied to Iranian patients.http://urologyjournal.org/index.php/uj/article/view/675/467. prostatic neoplasmprostate-specific antigenbenign prostate hyperplasiaearly detection of cancerbiopsy |
| spellingShingle | Khosro Rahbar Mohammadtaha Jalali Nasser Kamalian Javad Sanadizade Mohammad Sanadizade Faranak Kazerouni Houshang Amirrasouli Kamran Karimi Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population Urology Journal . prostatic neoplasm prostate-specific antigen benign prostate hyperplasia early detection of cancer biopsy |
| title | Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population |
| title_full | Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population |
| title_fullStr | Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population |
| title_full_unstemmed | Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population |
| title_short | Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population |
| title_sort | accurate cut off point for free to total prostate specific antigen ratio used to improve differentiation of prostate cancer from benign prostate hyperplasia in iranian population |
| topic | . prostatic neoplasm prostate-specific antigen benign prostate hyperplasia early detection of cancer biopsy |
| url | http://urologyjournal.org/index.php/uj/article/view/675/467 |
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