Immunoglobulin G1 and G2 profile in children with Down syndrome
Background and objectives: It is well known that children with Down syndrome (DS) suffer from frequent infections. There is an association of certain IgG subclass abnormalities with the predisposition to recurrent infection of the respiratory tract. Therefore, the study was conducted to determine th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Ibrahim Medical College
2017-01-01
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| Series: | IMC Journal of Medical Science |
| Online Access: | http://www.imcjms.com/registration/journal_full_text/157 |
| _version_ | 1818178302768054272 |
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| author | Supti Prava Saha Monsura Khan Ashesh Kumar Chowdhury |
| author_facet | Supti Prava Saha Monsura Khan Ashesh Kumar Chowdhury |
| author_sort | Supti Prava Saha |
| collection | DOAJ |
| description | Background and objectives: It is well known that children with Down syndrome (DS) suffer from frequent infections. There is an association of certain IgG subclass abnormalities with the predisposition to recurrent infection of the respiratory tract. Therefore, the study was conducted to determine the immunoglobulin G1 and G2 (IgG1, IgG2) profile in children with DS.
Material and methods: Forty children between the ages of 6 months to 12 years with DS (47 XX/XY, +21) attending the Department of Immunology, BIRDEM were enrolled in the study. Age and sex matched 30 healthy normal children with 46 XX/XY were included as control. Enrolled DS and healthy children were divided into two age groups namely 6 months to 6 years and 7 years to 12 years. Serum IgG1 and IgG2 concentrations were determined by enzyme linked immunosorbent assay (ELISA) method.
Results: The mean serum IgG1 concentrations of children with DS in both age groups did not differ significantly from that of normal healthy children. But the IgG2 level was significantly less (p<0.003 and p<0.004) in both age groups of children with DS compared to that of control healthy children.
Conclusion: The study has demonstrated that the serum IgG2 level was significantly less in children with DS than that of matched normal healthy control children while there was no deficiency of IgG1.
IMC J Med Sci 2017; 11(1): 1-4 |
| first_indexed | 2024-12-11T20:45:49Z |
| format | Article |
| id | doaj.art-9a1b4ebb036042b18297fcb506d8b1f0 |
| institution | Directory Open Access Journal |
| issn | 2519-1721 2519-1586 |
| language | English |
| last_indexed | 2024-12-11T20:45:49Z |
| publishDate | 2017-01-01 |
| publisher | Ibrahim Medical College |
| record_format | Article |
| series | IMC Journal of Medical Science |
| spelling | doaj.art-9a1b4ebb036042b18297fcb506d8b1f02022-12-22T00:51:22ZengIbrahim Medical CollegeIMC Journal of Medical Science2519-17212519-15862017-01-0111114Immunoglobulin G1 and G2 profile in children with Down syndromeSupti Prava Saha0Monsura Khan1Ashesh Kumar Chowdhury2Department of Immunology,Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder (BIRDEM),Shahbag, DhakaDepartment of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder (BIRDEM), Shahbag, DhakaDepartment of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder (BIRDEM), Shahbag, DhakaBackground and objectives: It is well known that children with Down syndrome (DS) suffer from frequent infections. There is an association of certain IgG subclass abnormalities with the predisposition to recurrent infection of the respiratory tract. Therefore, the study was conducted to determine the immunoglobulin G1 and G2 (IgG1, IgG2) profile in children with DS. Material and methods: Forty children between the ages of 6 months to 12 years with DS (47 XX/XY, +21) attending the Department of Immunology, BIRDEM were enrolled in the study. Age and sex matched 30 healthy normal children with 46 XX/XY were included as control. Enrolled DS and healthy children were divided into two age groups namely 6 months to 6 years and 7 years to 12 years. Serum IgG1 and IgG2 concentrations were determined by enzyme linked immunosorbent assay (ELISA) method. Results: The mean serum IgG1 concentrations of children with DS in both age groups did not differ significantly from that of normal healthy children. But the IgG2 level was significantly less (p<0.003 and p<0.004) in both age groups of children with DS compared to that of control healthy children. Conclusion: The study has demonstrated that the serum IgG2 level was significantly less in children with DS than that of matched normal healthy control children while there was no deficiency of IgG1. IMC J Med Sci 2017; 11(1): 1-4http://www.imcjms.com/registration/journal_full_text/157 |
| spellingShingle | Supti Prava Saha Monsura Khan Ashesh Kumar Chowdhury Immunoglobulin G1 and G2 profile in children with Down syndrome IMC Journal of Medical Science |
| title | Immunoglobulin G1 and G2 profile in children with Down syndrome |
| title_full | Immunoglobulin G1 and G2 profile in children with Down syndrome |
| title_fullStr | Immunoglobulin G1 and G2 profile in children with Down syndrome |
| title_full_unstemmed | Immunoglobulin G1 and G2 profile in children with Down syndrome |
| title_short | Immunoglobulin G1 and G2 profile in children with Down syndrome |
| title_sort | immunoglobulin g1 and g2 profile in children with down syndrome |
| url | http://www.imcjms.com/registration/journal_full_text/157 |
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