Sensitive remote homology search by local alignment of small positional embeddings from protein language models
Accurately detecting distant evolutionary relationships between proteins remains an ongoing challenge in bioinformatics. Search methods based on primary sequence struggle to accurately detect homology between sequences with less than 20% amino acid identity. Profile- and structure-based strategies e...
Main Authors: | Sean R Johnson, Meghana Peshwa, Zhiyi Sun |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/91415 |
Similar Items
-
Nearest neighbor search on embeddings rapidly identifies distant protein relations
by: Konstantin Schütze, et al.
Published: (2022-11-01) -
Insights into Comparative Modeling of V<sub>H</sub>H Domains
by: Akhila Melarkode Vattekatte, et al.
Published: (2021-09-01) -
SAFoldNet: A Novel Tool for Discovering and Aligning Three-Dimensional Protein Structures Based on a Neural Network
by: Denis V. Petrovskiy, et al.
Published: (2023-09-01) -
The prediction of the porcine pre-microRNAs in genome-wide based on support vector machine (SVM) and homology searching
by: Wang Zhen, et al.
Published: (2012-12-01) -
New Approach for Studying of Isoforms and High-Homology Proteins in Mammalian Cells
by: Nataliya V. Soshnikova, et al.
Published: (2023-07-01)