Centromeric KIR AA Individuals Harbor Particular KIR Alleles Conferring Beneficial NK Cell Features with Implications in Haplo-Identical Hematopoietic Stem Cell Transplantation

Centromeric KIR AA Individuals Harbor Particular KIR Alleles Conferring Beneficial NK Cell Features with Implications in Haplo-Identical Hematopoietic Stem Cell Transplantation

We have recently shown a broad disparity of Natural Killer (NK) cell responses against leukemia highlighting good and bad responders resting on the Killer cell Immunoglobulin-like Receptors (KIR) and HLA genetics. In this study, we deeply studied KIR2D allele expression, HLA-C recognition and functi...

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Bibliographic Details
Main Authors: Léa Dubreuil, Bercelin Maniangou, Patrice Chevallier, Agnès Quéméner, Nolwenn Legrand, Marie C. Béné, Catherine Willem, Gaëlle David, Mehdi Alizadeh, Dhon Roméo Makanga, Anne Cesbron, Ketevan Gendzekhadze, Katia Gagne, Christelle Retière
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
KIR
NK cells
haplo-identical HSCT
polymorphism
HLA
leukemia
Online Access:https://www.mdpi.com/2072-6694/12/12/3595

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