Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/57 |
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| author | Hardeep Singh Tuli Prangya Rath Abhishek Chauhan Anuj Ranjan Seema Ramniwas Katrin Sak Diwakar Aggarwal Manoj Kumar Kuldeep Dhama E Hui Clarissa Lee Kenneth Chun-Yong Yap Sharah Mae Capinpin Alan Prem Kumar |
| author_facet | Hardeep Singh Tuli Prangya Rath Abhishek Chauhan Anuj Ranjan Seema Ramniwas Katrin Sak Diwakar Aggarwal Manoj Kumar Kuldeep Dhama E Hui Clarissa Lee Kenneth Chun-Yong Yap Sharah Mae Capinpin Alan Prem Kumar |
| author_sort | Hardeep Singh Tuli |
| collection | DOAJ |
| description | Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium. |
| first_indexed | 2024-03-09T13:27:27Z |
| format | Article |
| id | doaj.art-9a1c3a6d79c9416a807529c0c5d9f75a |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9a1c3a6d79c9416a807529c0c5d9f75a2023-11-30T21:22:07ZengMDPI AGBiomolecules2218-273X2022-12-011315710.3390/biom13010057Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent TrendsHardeep Singh Tuli0Prangya Rath1Abhishek Chauhan2Anuj Ranjan3Seema Ramniwas4Katrin Sak5Diwakar Aggarwal6Manoj Kumar7Kuldeep Dhama8E Hui Clarissa Lee9Kenneth Chun-Yong Yap10Sharah Mae Capinpin11Alan Prem Kumar12Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, IndiaAmity Institute of Environmental Sciences, Amity University, Noida 201303, IndiaAmity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida 201303, IndiaAcademy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, RussiaUniversity Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali 140413, IndiaNGO Praeventio, 50407 Tartu, EstoniaDepartment of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, IndiaDepartment of Chemistry, Maharishi Markandeshwar University Sadopur, Ambala 134007, IndiaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly 243122, IndiaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeCucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.https://www.mdpi.com/2218-273X/13/1/57cucurbitacinsanti-proliferationapoptoticanti-angiogenicanti-metastaticsynergism |
| spellingShingle | Hardeep Singh Tuli Prangya Rath Abhishek Chauhan Anuj Ranjan Seema Ramniwas Katrin Sak Diwakar Aggarwal Manoj Kumar Kuldeep Dhama E Hui Clarissa Lee Kenneth Chun-Yong Yap Sharah Mae Capinpin Alan Prem Kumar Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends Biomolecules cucurbitacins anti-proliferation apoptotic anti-angiogenic anti-metastatic synergism |
| title | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| title_full | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| title_fullStr | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| title_full_unstemmed | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| title_short | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| title_sort | cucurbitacins as potent chemo preventive agents mechanistic insight and recent trends |
| topic | cucurbitacins anti-proliferation apoptotic anti-angiogenic anti-metastatic synergism |
| url | https://www.mdpi.com/2218-273X/13/1/57 |
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