Cellular Senescence in Aging Lungs and Diseases
Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/11/1781 |
| _version_ | 1827665347084288000 |
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| author | Arbi Aghali Maunick Lefin Koloko Ngassie Christina M. Pabelick Y. S. Prakash |
| author_facet | Arbi Aghali Maunick Lefin Koloko Ngassie Christina M. Pabelick Y. S. Prakash |
| author_sort | Arbi Aghali |
| collection | DOAJ |
| description | Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help to recognize the importance of such pathways in lung health and disease. There is increasing interest in the role of cellular senescence in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) in the context of understanding pathophysiology and identification of novel therapies. Herein, we discuss the current knowledge of molecular mechanisms and mitochondrial dysfunction regulating different aspects of cellular senescence-related to chronic lung diseases to develop rational strategies for modulating the senescent cell phenotype in the lung for therapeutic benefit. |
| first_indexed | 2024-03-10T01:25:00Z |
| format | Article |
| id | doaj.art-9a1d5ef73e5e4112b1c095f5f44a917d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:25:00Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9a1d5ef73e5e4112b1c095f5f44a917d2023-11-23T13:52:40ZengMDPI AGCells2073-44092022-05-011111178110.3390/cells11111781Cellular Senescence in Aging Lungs and DiseasesArbi Aghali0Maunick Lefin Koloko Ngassie1Christina M. Pabelick2Y. S. Prakash3Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USADepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USADepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USACellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help to recognize the importance of such pathways in lung health and disease. There is increasing interest in the role of cellular senescence in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) in the context of understanding pathophysiology and identification of novel therapies. Herein, we discuss the current knowledge of molecular mechanisms and mitochondrial dysfunction regulating different aspects of cellular senescence-related to chronic lung diseases to develop rational strategies for modulating the senescent cell phenotype in the lung for therapeutic benefit.https://www.mdpi.com/2073-4409/11/11/1781agingsenescencelung diseasesasthmaCOPDpulmonary fibrosis |
| spellingShingle | Arbi Aghali Maunick Lefin Koloko Ngassie Christina M. Pabelick Y. S. Prakash Cellular Senescence in Aging Lungs and Diseases Cells aging senescence lung diseases asthma COPD pulmonary fibrosis |
| title | Cellular Senescence in Aging Lungs and Diseases |
| title_full | Cellular Senescence in Aging Lungs and Diseases |
| title_fullStr | Cellular Senescence in Aging Lungs and Diseases |
| title_full_unstemmed | Cellular Senescence in Aging Lungs and Diseases |
| title_short | Cellular Senescence in Aging Lungs and Diseases |
| title_sort | cellular senescence in aging lungs and diseases |
| topic | aging senescence lung diseases asthma COPD pulmonary fibrosis |
| url | https://www.mdpi.com/2073-4409/11/11/1781 |
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