Immunotherapy for glioblastoma: the promise of combination strategies
Abstract Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The current standard of care involves surgical resection (if possible) followed by concomitant radiotherapy and chemotherapy. In recent years, immunotherapy strategies have revolutionized the treatment of man...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-022-02251-2 |
| _version_ | 1819231534720221184 |
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| author | Mathilde Bausart Véronique Préat Alessio Malfanti |
| author_facet | Mathilde Bausart Véronique Préat Alessio Malfanti |
| author_sort | Mathilde Bausart |
| collection | DOAJ |
| description | Abstract Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The current standard of care involves surgical resection (if possible) followed by concomitant radiotherapy and chemotherapy. In recent years, immunotherapy strategies have revolutionized the treatment of many cancers, increasing the hope for GBM therapy. However, mostly due to the high, multifactorial immunosuppression occurring in the microenvironment, the poor knowledge of the neuroimmune system and the presence of the blood−brain barrier, the efficacy of immunotherapy in GBM is still low. Recently, new strategies for GBM treatments have employed immunotherapy combinations and have provided encouraging results in both preclinical and clinical studies. The lessons learned from clinical trials highlight the importance of tackling different arms of immunity. In this review, we aim to summarize the preclinical evidence regarding combination immunotherapy in terms of immune and survival benefits for GBM management. The outcomes of recent studies assessing the combination of different classes of immunotherapeutic agents (e.g., immune checkpoint blockade and vaccines) will be discussed. Finally, future strategies to ameliorate the efficacy of immunotherapy and facilitate clinical translation will be provided to address the unmet medical needs of GBM. |
| first_indexed | 2024-12-23T11:46:30Z |
| format | Article |
| id | doaj.art-9a1fda044bd3412fba4a59d1669caa3a |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-23T11:46:30Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-9a1fda044bd3412fba4a59d1669caa3a2022-12-21T17:48:20ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662022-01-0141112210.1186/s13046-022-02251-2Immunotherapy for glioblastoma: the promise of combination strategiesMathilde Bausart0Véronique Préat1Alessio Malfanti2UCLouvain, Louvain Drug Research Institute, Advanced Drug Delivery and BiomaterialsUCLouvain, Louvain Drug Research Institute, Advanced Drug Delivery and BiomaterialsUCLouvain, Louvain Drug Research Institute, Advanced Drug Delivery and BiomaterialsAbstract Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The current standard of care involves surgical resection (if possible) followed by concomitant radiotherapy and chemotherapy. In recent years, immunotherapy strategies have revolutionized the treatment of many cancers, increasing the hope for GBM therapy. However, mostly due to the high, multifactorial immunosuppression occurring in the microenvironment, the poor knowledge of the neuroimmune system and the presence of the blood−brain barrier, the efficacy of immunotherapy in GBM is still low. Recently, new strategies for GBM treatments have employed immunotherapy combinations and have provided encouraging results in both preclinical and clinical studies. The lessons learned from clinical trials highlight the importance of tackling different arms of immunity. In this review, we aim to summarize the preclinical evidence regarding combination immunotherapy in terms of immune and survival benefits for GBM management. The outcomes of recent studies assessing the combination of different classes of immunotherapeutic agents (e.g., immune checkpoint blockade and vaccines) will be discussed. Finally, future strategies to ameliorate the efficacy of immunotherapy and facilitate clinical translation will be provided to address the unmet medical needs of GBM.https://doi.org/10.1186/s13046-022-02251-2Brain cancerGlioblastomaCombination immunotherapyImmune checkpoint blockadeCancer vaccine |
| spellingShingle | Mathilde Bausart Véronique Préat Alessio Malfanti Immunotherapy for glioblastoma: the promise of combination strategies Journal of Experimental & Clinical Cancer Research Brain cancer Glioblastoma Combination immunotherapy Immune checkpoint blockade Cancer vaccine |
| title | Immunotherapy for glioblastoma: the promise of combination strategies |
| title_full | Immunotherapy for glioblastoma: the promise of combination strategies |
| title_fullStr | Immunotherapy for glioblastoma: the promise of combination strategies |
| title_full_unstemmed | Immunotherapy for glioblastoma: the promise of combination strategies |
| title_short | Immunotherapy for glioblastoma: the promise of combination strategies |
| title_sort | immunotherapy for glioblastoma the promise of combination strategies |
| topic | Brain cancer Glioblastoma Combination immunotherapy Immune checkpoint blockade Cancer vaccine |
| url | https://doi.org/10.1186/s13046-022-02251-2 |
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