Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver DiseaseSummary

Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver DiseaseSummary

Background & Aims: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration. We aimed to define the role of Smoothene...

Full description

Bibliographic Details
Main Authors:	Tianyi Chen, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, Manal F. Abdelmalek, Ricardo Henao, Paolo Guarnieri, Steven S. Pullen, Simon Gregory, Joseph Locker, J. Mark Brown, Anna Mae Diehl
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Cellular and Molecular Gastroenterology and Hepatology
Subjects:	hedgehog nonalcoholic fatty liver disease metabolic syndrome
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X22002569

Similar Items

Caspase-11–Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic SteatohepatitisSummary
by: Yingwei Zhu, et al.
Published: (2021-01-01)

Loss of pericyte smoothened activity in mice with genetic deficiency of leptin
by: Guanhua Xie, et al.
Published: (2017-04-01)

The Role of Smoothened in Cancer
by: Kuo-Shyang Jeng, et al.
Published: (2020-09-01)

Metabolic Targets in Nonalcoholic Fatty Liver DiseaseSummary
by: William P. Esler, et al.
Published: (2019-01-01)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
by: Jie Zhang, et al.
Published: (2021-08-01)

Serum Metabolites Are Associated With HFpEF in Biopsy‐Proven Nonalcoholic Fatty Liver Disease
by: Kara Wegermann, et al.
Published: (2023-07-01)

mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease
by: Jiayao Feng, et al.
Published: (2022-08-01)

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver DiseaseSummary
by: Emmelie Cansby, et al.
Published: (2019-01-01)

White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in MiceSummary
by: Sadatsugu Sakane, et al.
Published: (2021-01-01)

Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells
by: Hong Lou, et al.
Published: (2020-08-01)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
by: Sigrid Nachtergaele, et al.
Published: (2013-10-01)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
by: Zhao, Zhonghua, et al.
Published: (2016)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
by: Byrne, E
Published: (2017)

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver DiseaseSummary
by: Leke Wiering, et al.
Published: (2023-01-01)

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
by: George D. Dalton, et al.
Published: (2021-09-01)

Contributions of Noncanonical Smoothened Signaling During Embryonic Development
by: Tanushree Pandit, et al.
Published: (2017-10-01)

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma
by: Ana Dunatov Huljev, et al.
Published: (2023-05-01)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
by: Giovanni Luchetti, et al.
Published: (2016-10-01)

Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation
by: Alice Del Giovane, et al.
Published: (2022-01-01)

A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy
by: Junwan Fan, et al.
Published: (2022-11-01)

Identification of a potent antagonist of smoothened in hedgehog signaling
by: Junwan Fan, et al.
Published: (2021-03-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
by: Silvia Pietrobono, et al.
Published: (2018-12-01)

Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human HepatocytesSummary
by: Letao Fan, et al.
Published: (2023-01-01)

Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis
by: Kota Saito, et al.
Published: (2024-02-01)

The Gut Microbiota and Liver DiseaseSummary
by: Cristina Llorente, et al.
Published: (2015-05-01)

Recent update: Nonalcoholic steatohepatitis
by: Vivek Hande, et al.
Published: (2018-01-01)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
by: Silvia Pietrobono, et al.
Published: (2019-06-01)

Does Nonalcoholic Pancreatic Steatosis Always Correlate with Nonalcoholic Fatty Liver Disease?
by: Ulasoglu C, et al.
Published: (2021-06-01)

Sesamin ameliorates nonalcoholic steatohepatitis through inhibiting hepatocyte pyroptosis in vivo and in vitro
by: Teng Zhang, et al.
Published: (2024-02-01)

The cation-π interaction in cysteine-rich domain of Smoothened is critical for its cholesterylation and function
by: Kong Zekai, et al.
Published: (2022-07-01)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
by: Jian Yi Chai, et al.
Published: (2021-09-01)

The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes
by: Andrés Vicente-Acosta, et al.
Published: (2022-04-01)

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
by: Tadas K. Rimkus, et al.
Published: (2016-02-01)

Disease Progression in a Patient with Nonalcoholic Steatohepatitis
by: Ping-Huei Tseng, et al.
Published: (2008-10-01)

Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
by: Seonghwan Hwang, et al.
Published: (2021-10-01)

Novel Nondietary Therapies for Celiac DiseaseSummary
by: Eaman Alhassan, et al.
Published: (2019-01-01)

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia
by: Ping Shi, et al.
Published: (2023-09-01)

Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis
by: Bing Yang, et al.
Published: (2022-09-01)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
by: Marina Gonçalves Antunes, et al.
Published: (2022-09-01)

Corrigendum: Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis
by: Bing Yang, et al.
Published: (2023-09-01)