Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021)
Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in patients who attended a referral care center in Argentin...
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Permanyer
2024-01-01
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| Series: | Revista de Investigación Clínica |
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| Online Access: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=491 |
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| author | Natalia J. López Solange Arazi-Caillaud Rosa M. Bologna Andrea M. Mangano Cristina P. Aulicino |
| author_facet | Natalia J. López Solange Arazi-Caillaud Rosa M. Bologna Andrea M. Mangano Cristina P. Aulicino |
| author_sort | Natalia J. López |
| collection | DOAJ |
| description | Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in patients who attended a referral care center in Argentina over a 15-year period and to compare mutational patterns between HIV-1 pol sequences characterized as B or BF recombinants. Methods: Individual resistance-associated mutations (RAMs) (to protease and reverse transcriptase inhibitors) were identified according to IAS-USA guidelines in 374 HIV-1-infected children and adolescents. HIV-1 subtype was characterized by phylogenetic and recombination analysis using MEGA5.1 and Simplot. Poisson linear regression was used to model the dynamics of the RAMs over time. Results: The prevalence of RAMs to protease inhibitors (R2 = 0.52, p = 0.0012) and nucleoside reverse transcriptase inhibitors (R2 = 0.30, p = 0.0225) decreased over time. HIVDR to non-nucleoside reverse transcriptase inhibitors remained moderate to high, ranging between 33% and 76%. BF recombinants showed a higher frequency of thymidine analog mutation 1 RAMs profile and I54V mutation. Conclusion: In Argentina, HIVDR observed in children and adolescents has decreased over the past 15 years, regardless of the viral subtype.
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| first_indexed | 2024-03-07T14:37:57Z |
| format | Article |
| id | doaj.art-9a2044dcdf574882838a28d22a9d2b6f |
| institution | Directory Open Access Journal |
| issn | 0034-8376 2564-8896 |
| language | English |
| last_indexed | 2024-03-07T14:37:57Z |
| publishDate | 2024-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista de Investigación Clínica |
| spelling | doaj.art-9a2044dcdf574882838a28d22a9d2b6f2024-03-05T20:31:57ZengPermanyerRevista de Investigación Clínica0034-83762564-88962024-01-0176110.24875/RIC.23000210Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021)Natalia J. López0Solange Arazi-Caillaud1Rosa M. Bologna2Andrea M. Mangano3Cristina P. Aulicino4Laboratorio de Biología Celular y Retrovirus (BCYR), Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, ArgentinaEpidemiology Service, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, ArgentinaEpidemiology Service, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, ArgentinaLaboratorio de Biología Celular y Retrovirus (BCYR), Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, ArgentinaLaboratorio de Biología Celular y Retrovirus (BCYR), Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, ArgentinaBackground: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in patients who attended a referral care center in Argentina over a 15-year period and to compare mutational patterns between HIV-1 pol sequences characterized as B or BF recombinants. Methods: Individual resistance-associated mutations (RAMs) (to protease and reverse transcriptase inhibitors) were identified according to IAS-USA guidelines in 374 HIV-1-infected children and adolescents. HIV-1 subtype was characterized by phylogenetic and recombination analysis using MEGA5.1 and Simplot. Poisson linear regression was used to model the dynamics of the RAMs over time. Results: The prevalence of RAMs to protease inhibitors (R2 = 0.52, p = 0.0012) and nucleoside reverse transcriptase inhibitors (R2 = 0.30, p = 0.0225) decreased over time. HIVDR to non-nucleoside reverse transcriptase inhibitors remained moderate to high, ranging between 33% and 76%. BF recombinants showed a higher frequency of thymidine analog mutation 1 RAMs profile and I54V mutation. Conclusion: In Argentina, HIVDR observed in children and adolescents has decreased over the past 15 years, regardless of the viral subtype. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=491Human immunodeficiency virus. Resistance. Human immunodeficiency virus subtypes. |
| spellingShingle | Natalia J. López Solange Arazi-Caillaud Rosa M. Bologna Andrea M. Mangano Cristina P. Aulicino Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) Revista de Investigación Clínica Human immunodeficiency virus. Resistance. Human immunodeficiency virus subtypes. |
| title | Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) |
| title_full | Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) |
| title_fullStr | Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) |
| title_full_unstemmed | Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) |
| title_short | Longitudinal Trends in HIV-1 Subtypes and Drug Resistance in Children from Argentina over a 15-Year Period (2006-2021) |
| title_sort | longitudinal trends in hiv 1 subtypes and drug resistance in children from argentina over a 15 year period 2006 2021 |
| topic | Human immunodeficiency virus. Resistance. Human immunodeficiency virus subtypes. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=491 |
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