Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctata

Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctata

Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential for plasmalogen biosynthesis. Plasmalogens are a class of membrane glycerophospholipids containing a vinyl-ether-linked fatty alcohol at the sn-1 position that affect functions i...

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Bibliographic Details
Main Authors: Wedad Fallatah, Tara Smith, Wei Cui, Dushmanthi Jayasinghe, Erminia Di Pietro, Shawn A. Ritchie, Nancy Braverman
Format: Article
Language:English
Published: The Company of Biologists 2020-01-01
Series:Disease Models & Mechanisms
Subjects:
ppi-1040
rhizomelic chondrodysplasia punctata
rcdp
peroxisomal disorder
plasmalogen
Online Access:http://dmm.biologists.org/content/13/1/dmm042499

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