Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway
Abstract Previous epidemiological and histopathological studies have demonstrated that long‐term computation of Kweichow Moutai liquor (Moutai) could induce fatty liver disease but few of these patients with fatty liver will develop hepatic fibrosis or cirrhosis. Moutai liquor has a different brewin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-08-01
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| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.1716 |
| _version_ | 1797661200695164928 |
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| author | Tao Yang Yu Feng Yifan Zhang Wei Wang Shutian Zhang Sijin Yang Ming Hong |
| author_facet | Tao Yang Yu Feng Yifan Zhang Wei Wang Shutian Zhang Sijin Yang Ming Hong |
| author_sort | Tao Yang |
| collection | DOAJ |
| description | Abstract Previous epidemiological and histopathological studies have demonstrated that long‐term computation of Kweichow Moutai liquor (Moutai) could induce fatty liver disease but few of these patients with fatty liver will develop hepatic fibrosis or cirrhosis. Moutai liquor has a different brewing technique from other white wine, which may generate various microorganisms in the unique geographical conditions and may produce plenty of vitamins, amino acids, and several essential microelements. In the current study, we evaluated the potential protective effect of Moutai liquor in alcohol‐induced liver fibrosis mouse model. Both in vivo and in vitro studies were performed for exploring the possible mechanisms in suppressing liver fibrosis by Moutai. We demonstrated that Moutai treatment induced hepatic stellate cell (HSC) apoptosis and suppressed collagen deposition, as well as attenuated hepatic fibrosis. The antifibrosis mechanism of Moutai was possibly related with the inhibition of Kupffer cell and HSC activation via suppressing NFκB nuclear translocation and preventing the expression of pro‐inflammatory cytokines. It is worth noting that although Moutai attenuates liver fibrosis, it still causes lipid metabolic abnormalities in mouse liver and induces fatty liver. Kweichow Moutai may ameliorate alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway. |
| first_indexed | 2024-03-11T18:41:54Z |
| format | Article |
| id | doaj.art-9a23cff424e2491ab8e15e6c4b238e43 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-11T18:41:54Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-9a23cff424e2491ab8e15e6c4b238e432023-10-12T12:06:11ZengWileyFood Science & Nutrition2048-71772020-08-01884214422210.1002/fsn3.1716Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathwayTao Yang0Yu Feng1Yifan Zhang2Wei Wang3Shutian Zhang4Sijin Yang5Ming Hong6Department of General Surgery The First Affiliated Hospital of Jinzhou Medical University Jinzhou ChinaDepartment of Traumatology General Hospital of Ningxia Medical University Yinchuan ChinaDepartment of General Surgery The First Affiliated Hospital of Jinzhou Medical University Jinzhou ChinaDepartment of General Surgery The First Affiliated Hospital of Jinzhou Medical University Jinzhou ChinaDepartment of General Surgery The First Affiliated Hospital of Jinzhou Medical University Jinzhou ChinaSouthwestern Medical University Affiliated Chinese Medicine Hospital Luzhou ChinaScience and Technology Innovation Center Guangzhou University of Chinese Medicine Guangzhou ChinaAbstract Previous epidemiological and histopathological studies have demonstrated that long‐term computation of Kweichow Moutai liquor (Moutai) could induce fatty liver disease but few of these patients with fatty liver will develop hepatic fibrosis or cirrhosis. Moutai liquor has a different brewing technique from other white wine, which may generate various microorganisms in the unique geographical conditions and may produce plenty of vitamins, amino acids, and several essential microelements. In the current study, we evaluated the potential protective effect of Moutai liquor in alcohol‐induced liver fibrosis mouse model. Both in vivo and in vitro studies were performed for exploring the possible mechanisms in suppressing liver fibrosis by Moutai. We demonstrated that Moutai treatment induced hepatic stellate cell (HSC) apoptosis and suppressed collagen deposition, as well as attenuated hepatic fibrosis. The antifibrosis mechanism of Moutai was possibly related with the inhibition of Kupffer cell and HSC activation via suppressing NFκB nuclear translocation and preventing the expression of pro‐inflammatory cytokines. It is worth noting that although Moutai attenuates liver fibrosis, it still causes lipid metabolic abnormalities in mouse liver and induces fatty liver. Kweichow Moutai may ameliorate alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway.https://doi.org/10.1002/fsn3.1716hepatic stellate cellliver fibrosisMoutai liquorNFκB |
| spellingShingle | Tao Yang Yu Feng Yifan Zhang Wei Wang Shutian Zhang Sijin Yang Ming Hong Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway Food Science & Nutrition hepatic stellate cell liver fibrosis Moutai liquor NFκB |
| title | Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway |
| title_full | Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway |
| title_fullStr | Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway |
| title_full_unstemmed | Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway |
| title_short | Retracted: Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway |
| title_sort | retracted kweichow moutai ameliorates alcohol induced liver fibrosis in mice by targeting the nfκb pathway |
| topic | hepatic stellate cell liver fibrosis Moutai liquor NFκB |
| url | https://doi.org/10.1002/fsn3.1716 |
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