Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP)
Objectives: To assess the effectiveness of two consecutive intraarticular injections of PRP to treat knee osteoarthritis (KOA), discriminating between responders and impaired patients. Methods: This retrospective study included 73 consecutive patients who were referred for two intra-articular PRP in...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/8/922 |
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| author | Alain Silvestre Pierre-Francois Lintingre Lionel Pesquer Philippe Meyer Marie-Hélène Moreau-Durieux Benjamin Dallaudiére |
| author_facet | Alain Silvestre Pierre-Francois Lintingre Lionel Pesquer Philippe Meyer Marie-Hélène Moreau-Durieux Benjamin Dallaudiére |
| author_sort | Alain Silvestre |
| collection | DOAJ |
| description | Objectives: To assess the effectiveness of two consecutive intraarticular injections of PRP to treat knee osteoarthritis (KOA), discriminating between responders and impaired patients. Methods: This retrospective study included 73 consecutive patients who were referred for two intra-articular PRP injections (one week apart) for treating symptomatic moderate/severe KOA. Biological characterization of the PRP, including platelets, leukocytes and erythrocytes, was evaluated. Patient’s subjective symptoms were recorded before the treatment and 1 year after the second injection using pain VAS and WOMAC scores. Responders were defined by an improvement of 10 points on WOMAC. Results: At a 1-year follow up, we found 36 (49.3%) patients who fulfilled the criteria of responders, and 21 (28.8%) patients were impaired. A statistically and clinically significant global improvement of −29.2 ± 14.3 (<i>p</i> < 0.001) points in WOMAC score was observed 1 year after treatment in the responder group, with a higher response rate in patients with KL 2 (57.7%) compared to KL IV (28.6%). The percentage of patients with KL IV was higher in the impaired group (48.0%) compared to the responders (16.6%). As expected, the evaluation of the functionality of the knee in the impaired group indicates that it significantly worsened after one year from treatment (<i>p</i> = 0.027). However, the average pain score remained stable with no significant differences after 1 year (<i>p</i> = 0.843). No clinical complications or severe adverse events after the PRP injections were reported. Conclusion: The present study suggests that two intra-articular injections of 10 mL of very pure PRP provide pain and functional improvement in symptomatic KOA. |
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| language | English |
| last_indexed | 2024-03-11T00:06:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-9a277f0580ba40d88b36c1d49f4b731c2023-11-19T00:17:53ZengMDPI AGBioengineering2306-53542023-08-0110892210.3390/bioengineering10080922Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP)Alain Silvestre0Pierre-Francois Lintingre1Lionel Pesquer2Philippe Meyer3Marie-Hélène Moreau-Durieux4Benjamin Dallaudiére5Clinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceClinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceClinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceClinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceClinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceClinique du Sport de Bordeaux Mérignac, 33700 Mérignac, FranceObjectives: To assess the effectiveness of two consecutive intraarticular injections of PRP to treat knee osteoarthritis (KOA), discriminating between responders and impaired patients. Methods: This retrospective study included 73 consecutive patients who were referred for two intra-articular PRP injections (one week apart) for treating symptomatic moderate/severe KOA. Biological characterization of the PRP, including platelets, leukocytes and erythrocytes, was evaluated. Patient’s subjective symptoms were recorded before the treatment and 1 year after the second injection using pain VAS and WOMAC scores. Responders were defined by an improvement of 10 points on WOMAC. Results: At a 1-year follow up, we found 36 (49.3%) patients who fulfilled the criteria of responders, and 21 (28.8%) patients were impaired. A statistically and clinically significant global improvement of −29.2 ± 14.3 (<i>p</i> < 0.001) points in WOMAC score was observed 1 year after treatment in the responder group, with a higher response rate in patients with KL 2 (57.7%) compared to KL IV (28.6%). The percentage of patients with KL IV was higher in the impaired group (48.0%) compared to the responders (16.6%). As expected, the evaluation of the functionality of the knee in the impaired group indicates that it significantly worsened after one year from treatment (<i>p</i> = 0.027). However, the average pain score remained stable with no significant differences after 1 year (<i>p</i> = 0.843). No clinical complications or severe adverse events after the PRP injections were reported. Conclusion: The present study suggests that two intra-articular injections of 10 mL of very pure PRP provide pain and functional improvement in symptomatic KOA.https://www.mdpi.com/2306-5354/10/8/922knee jointosteoarthritiscartilageintra-articular injectionplatelet-rich plasma |
| spellingShingle | Alain Silvestre Pierre-Francois Lintingre Lionel Pesquer Philippe Meyer Marie-Hélène Moreau-Durieux Benjamin Dallaudiére Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) Bioengineering knee joint osteoarthritis cartilage intra-articular injection platelet-rich plasma |
| title | Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) |
| title_full | Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) |
| title_fullStr | Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) |
| title_full_unstemmed | Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) |
| title_short | Retrospective Analysis of Responders and Impaired Patients with Knee Osteoarthritis Treated with Two Consecutive Injections of Very Pure Platelet-Rich Plasma (PRP) |
| title_sort | retrospective analysis of responders and impaired patients with knee osteoarthritis treated with two consecutive injections of very pure platelet rich plasma prp |
| topic | knee joint osteoarthritis cartilage intra-articular injection platelet-rich plasma |
| url | https://www.mdpi.com/2306-5354/10/8/922 |
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