Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme
Abstract Radiotherapy is an essential step during the treatment of glioblastoma multiforme (GBM), one of the most lethal malignancies. The survival in patients with GBM was improved by the current standard of care for GBM established in 2005 but has stagnated since then. Since GBM is a radioresistan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00684-5 |
| _version_ | 1798042134160343040 |
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| author | Jinyeong Choi Gaeun Kim Su Bin Cho Hyung-Jun Im |
| author_facet | Jinyeong Choi Gaeun Kim Su Bin Cho Hyung-Jun Im |
| author_sort | Jinyeong Choi |
| collection | DOAJ |
| description | Abstract Radiotherapy is an essential step during the treatment of glioblastoma multiforme (GBM), one of the most lethal malignancies. The survival in patients with GBM was improved by the current standard of care for GBM established in 2005 but has stagnated since then. Since GBM is a radioresistant malignancy and the most of GBM recurrences occur in the radiotherapy field, increasing the effectiveness of radiotherapy using high-Z metal nanoparticles (NPs) has recently attracted attention. This review summarizes the progress in radiotherapy approaches for the current treatment of GBM, the physical and biological mechanisms of radiosensitization through high-Z metal NPs, and the results of studies on radiosensitization in the in vitro and in vivo GBM models using high-Z metal NPs to date. |
| first_indexed | 2024-04-11T22:31:18Z |
| format | Article |
| id | doaj.art-9a29362451b549be9bd716cecfe32ba0 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:31:18Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-9a29362451b549be9bd716cecfe32ba02022-12-22T03:59:24ZengBMCJournal of Nanobiotechnology1477-31552020-09-0118112310.1186/s12951-020-00684-5Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiformeJinyeong Choi0Gaeun Kim1Su Bin Cho2Hyung-Jun Im3Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National UniversityDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National UniversityDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National UniversityDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National UniversityAbstract Radiotherapy is an essential step during the treatment of glioblastoma multiforme (GBM), one of the most lethal malignancies. The survival in patients with GBM was improved by the current standard of care for GBM established in 2005 but has stagnated since then. Since GBM is a radioresistant malignancy and the most of GBM recurrences occur in the radiotherapy field, increasing the effectiveness of radiotherapy using high-Z metal nanoparticles (NPs) has recently attracted attention. This review summarizes the progress in radiotherapy approaches for the current treatment of GBM, the physical and biological mechanisms of radiosensitization through high-Z metal NPs, and the results of studies on radiosensitization in the in vitro and in vivo GBM models using high-Z metal NPs to date.http://link.springer.com/article/10.1186/s12951-020-00684-5RadiotherapyGold nanoparticleGlioblastomaRadiosensitizationHigh-Z material |
| spellingShingle | Jinyeong Choi Gaeun Kim Su Bin Cho Hyung-Jun Im Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme Journal of Nanobiotechnology Radiotherapy Gold nanoparticle Glioblastoma Radiosensitization High-Z material |
| title | Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| title_full | Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| title_fullStr | Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| title_full_unstemmed | Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| title_short | Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| title_sort | radiosensitizing high z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme |
| topic | Radiotherapy Gold nanoparticle Glioblastoma Radiosensitization High-Z material |
| url | http://link.springer.com/article/10.1186/s12951-020-00684-5 |
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