Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials
The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/15/9/272 |
| _version_ | 1811299683041017856 |
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| author | Alka Choudhary Lynn M. Naughton Itxaso Montánchez Alan D. W. Dobson Dilip K. Rai |
| author_facet | Alka Choudhary Lynn M. Naughton Itxaso Montánchez Alan D. W. Dobson Dilip K. Rai |
| author_sort | Alka Choudhary |
| collection | DOAJ |
| description | The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds. |
| first_indexed | 2024-04-13T06:40:25Z |
| format | Article |
| id | doaj.art-9a2ba93233c2486384016f7eb6d62481 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T06:40:25Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9a2ba93233c2486384016f7eb6d624812022-12-22T02:57:46ZengMDPI AGMarine Drugs1660-33972017-08-0115927210.3390/md15090272md15090272Current Status and Future Prospects of Marine Natural Products (MNPs) as AntimicrobialsAlka Choudhary0Lynn M. Naughton1Itxaso Montánchez2Alan D. W. Dobson3Dilip K. Rai4Department of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, IrelandSchool of Microbiology, University College Cork, Western Road, Cork City T12 YN60, IrelandDepartment of Immunology, Microbiology and Parasitology, Faculty of Science, University of the Basque Country, (UPV/EHU), 48940 Leioa, SpainSchool of Microbiology, University College Cork, Western Road, Cork City T12 YN60, IrelandDepartment of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, IrelandThe marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.https://www.mdpi.com/1660-3397/15/9/272antimicrobialmarine natural products (MNPs)secondary metabolitesantibacterialantifungalgenome mining |
| spellingShingle | Alka Choudhary Lynn M. Naughton Itxaso Montánchez Alan D. W. Dobson Dilip K. Rai Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials Marine Drugs antimicrobial marine natural products (MNPs) secondary metabolites antibacterial antifungal genome mining |
| title | Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials |
| title_full | Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials |
| title_fullStr | Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials |
| title_full_unstemmed | Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials |
| title_short | Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials |
| title_sort | current status and future prospects of marine natural products mnps as antimicrobials |
| topic | antimicrobial marine natural products (MNPs) secondary metabolites antibacterial antifungal genome mining |
| url | https://www.mdpi.com/1660-3397/15/9/272 |
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