Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology

With the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been...

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Main Authors: M. I. Rachkovskiy, I. A. Goncharova, E. I. Beloborodova, Ye. V. Beloborodova, Ye. G. Gruzdeva, A. S. Alekseyeva, V. P. Puzyryov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2009-04-01
Series:Бюллетень сибирской медицины
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Online Access:https://bulletin.ssmu.ru/jour/article/view/1813
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author M. I. Rachkovskiy
I. A. Goncharova
E. I. Beloborodova
Ye. V. Beloborodova
Ye. G. Gruzdeva
A. S. Alekseyeva
V. P. Puzyryov
author_facet M. I. Rachkovskiy
I. A. Goncharova
E. I. Beloborodova
Ye. V. Beloborodova
Ye. G. Gruzdeva
A. S. Alekseyeva
V. P. Puzyryov
author_sort M. I. Rachkovskiy
collection DOAJ
description With the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been В С compared a frequencies of allocation of polymorphic variants of genes GSTP1 and GSTM1 between the died and persisted patients for the season 4 years. With greater survival rate of sick of LC associated: presence of genotype АА of gene GSTP1 (χ 2 Pearson, р = 0,008) and «null» genotype GSTM1 (χ 2 Pearson, р = 0,027). Chances of development of a lethal outcome at sick of LC with presence of genotypes GG and AG on gene GSTP1 in 2,5 times above, than at patients with genotype АА. Presence of active gene replica GSTM1 enlarges chances of development of a lethal outcome in 2 times. The received results testify to necessity of the count of genetical factors for the forecast of LC.
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spelling doaj.art-9a2bcf89de7c4078a6fb6842bcaf4fe02023-03-13T09:58:11ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842009-04-0182454910.20538/1682-0363-2009-2-45-491309Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiologyM. I. Rachkovskiy0I. A. Goncharova1E. I. Beloborodova2Ye. V. Beloborodova3Ye. G. Gruzdeva4A. S. Alekseyeva5V. P. Puzyryov6Сибирский государственный медицинский университетНИИ медицинской генетики СО РАМНСибирский государственный медицинский университетСибирский государственный медицинский университетОГУЗ «Томская областная клиническая больница»ОГУЗ «Томская областная клиническая больница»НИИ медицинской генетики СО РАМНWith the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been В С compared a frequencies of allocation of polymorphic variants of genes GSTP1 and GSTM1 between the died and persisted patients for the season 4 years. With greater survival rate of sick of LC associated: presence of genotype АА of gene GSTP1 (χ 2 Pearson, р = 0,008) and «null» genotype GSTM1 (χ 2 Pearson, р = 0,027). Chances of development of a lethal outcome at sick of LC with presence of genotypes GG and AG on gene GSTP1 in 2,5 times above, than at patients with genotype АА. Presence of active gene replica GSTM1 enlarges chances of development of a lethal outcome in 2 times. The received results testify to necessity of the count of genetical factors for the forecast of LC.https://bulletin.ssmu.ru/jour/article/view/1813полиморфизм геновцирроз печенипрогноз
spellingShingle M. I. Rachkovskiy
I. A. Goncharova
E. I. Beloborodova
Ye. V. Beloborodova
Ye. G. Gruzdeva
A. S. Alekseyeva
V. P. Puzyryov
Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
Бюллетень сибирской медицины
полиморфизм генов
цирроз печени
прогноз
title Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
title_full Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
title_fullStr Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
title_full_unstemmed Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
title_short Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
title_sort analysis of association of polymorphic variants of genes gstp1 and gstm1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
topic полиморфизм генов
цирроз печени
прогноз
url https://bulletin.ssmu.ru/jour/article/view/1813
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