Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV
We investigated whether blood telomere length (TL), epigenetic age acceleration (EAA), and soluble inflammatory monocyte cytokines are associated with cardiovascular events or diabetes (DM) in people living with HIV (PLHIV). This was a case–control study nested in the Spanish HIV/AIDS Cohort (CoRIS)...
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MDPI AG
2023-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/7/1818 |
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| author | Jose I. Bernardino Belen Alejos Javier Rodriguez-Centeno Andrés Esteban-Cantos Beatriz Mora-Rojas Rocío Montejano Rosa De Miguel Marta Montero-Alonso Oskar Ayerdi Cristina Hernández-Gutierrez Adriá Curran Jose R. Arribas Berta Rodés |
| author_facet | Jose I. Bernardino Belen Alejos Javier Rodriguez-Centeno Andrés Esteban-Cantos Beatriz Mora-Rojas Rocío Montejano Rosa De Miguel Marta Montero-Alonso Oskar Ayerdi Cristina Hernández-Gutierrez Adriá Curran Jose R. Arribas Berta Rodés |
| author_sort | Jose I. Bernardino |
| collection | DOAJ |
| description | We investigated whether blood telomere length (TL), epigenetic age acceleration (EAA), and soluble inflammatory monocyte cytokines are associated with cardiovascular events or diabetes (DM) in people living with HIV (PLHIV). This was a case–control study nested in the Spanish HIV/AIDS Cohort (CoRIS). Cases with myocardial infarction, stroke, sudden death, or diabetes after starting antiretroviral therapy were included with the available samples and controls matched for sex, age, tobacco use, pre-ART CD4 cell count, viral load, and sample time-point. TL (T/S ratio) was analysed by quantitative PCR and EAA with DNA methylation changes by next-generation sequencing using the Weidner formula. Conditional logistic regression was used to explore the association with cardiometabolic events. In total, 180 participants (94 cases (22 myocardial infarction/sudden death, 12 strokes, and 60 DM) and 94 controls) were included. Of these, 84% were male, median (IQR) age 46 years (40–56), 53% were current smokers, and 22% had CD4 count ≤ 200 cells/mm<sup>3</sup> and a median (IQR) log viral load of 4.52 (3.77–5.09). TL and EAA were similar in the cases and controls. There were no significant associations between TL, EAA, and monocyte cytokines with cardiometabolic events. TL and EAA were mildly negatively correlated with sCD14 (rho = −0.23; <i>p</i> = 0.01) and CCL2/MCP-1 (rho = −0.17; <i>p</i> = 0.02). We found no associations between TL, EAA, and monocyte cytokines with cardiovascular events or diabetes. Further studies are needed to elucidate the clinical value of epigenetic biomarkers and TL in PLHIV. |
| first_indexed | 2024-03-11T00:48:05Z |
| format | Article |
| id | doaj.art-9a2bf89512b0453db6f114a2b8aeb4ac |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T00:48:05Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9a2bf89512b0453db6f114a2b8aeb4ac2023-11-18T20:36:53ZengMDPI AGMicroorganisms2076-26072023-07-01117181810.3390/microorganisms11071818Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIVJose I. Bernardino0Belen Alejos1Javier Rodriguez-Centeno2Andrés Esteban-Cantos3Beatriz Mora-Rojas4Rocío Montejano5Rosa De Miguel6Marta Montero-Alonso7Oskar Ayerdi8Cristina Hernández-Gutierrez9Adriá Curran10Jose R. Arribas11Berta Rodés12Unidad de VIH, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainCentro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, SpainCIBERINFECC, Instituto de Salud Carlos III, 28029 Madrid, SpainCIBERINFECC, Instituto de Salud Carlos III, 28029 Madrid, SpainCIBERINFECC, Instituto de Salud Carlos III, 28029 Madrid, SpainUnidad de VIH, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainUnidad de VIH, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainUnidad de Enfermedades Infecciosas, Hospital Universitario y Politécnico La Fe, 46026 Valencia, SpainCentro Sanitario Sandoval, Hospital Clínico San Carlos, IdiSSSC, 28010 Madrid, SpainDepartamento de Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, 28805 Madrid, SpainDepartamento Enfermedades Infecciosas, Hospital Universitari Vall d’Hebron, VHIR, 08035 Barcelona, SpainUnidad de VIH, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainCIBERINFECC, Instituto de Salud Carlos III, 28029 Madrid, SpainWe investigated whether blood telomere length (TL), epigenetic age acceleration (EAA), and soluble inflammatory monocyte cytokines are associated with cardiovascular events or diabetes (DM) in people living with HIV (PLHIV). This was a case–control study nested in the Spanish HIV/AIDS Cohort (CoRIS). Cases with myocardial infarction, stroke, sudden death, or diabetes after starting antiretroviral therapy were included with the available samples and controls matched for sex, age, tobacco use, pre-ART CD4 cell count, viral load, and sample time-point. TL (T/S ratio) was analysed by quantitative PCR and EAA with DNA methylation changes by next-generation sequencing using the Weidner formula. Conditional logistic regression was used to explore the association with cardiometabolic events. In total, 180 participants (94 cases (22 myocardial infarction/sudden death, 12 strokes, and 60 DM) and 94 controls) were included. Of these, 84% were male, median (IQR) age 46 years (40–56), 53% were current smokers, and 22% had CD4 count ≤ 200 cells/mm<sup>3</sup> and a median (IQR) log viral load of 4.52 (3.77–5.09). TL and EAA were similar in the cases and controls. There were no significant associations between TL, EAA, and monocyte cytokines with cardiometabolic events. TL and EAA were mildly negatively correlated with sCD14 (rho = −0.23; <i>p</i> = 0.01) and CCL2/MCP-1 (rho = −0.17; <i>p</i> = 0.02). We found no associations between TL, EAA, and monocyte cytokines with cardiovascular events or diabetes. Further studies are needed to elucidate the clinical value of epigenetic biomarkers and TL in PLHIV.https://www.mdpi.com/2076-2607/11/7/1818HIV infectionblood telomere lengthepigenetic age accelerationmonocyte activationcardiovascular diseasediabetes |
| spellingShingle | Jose I. Bernardino Belen Alejos Javier Rodriguez-Centeno Andrés Esteban-Cantos Beatriz Mora-Rojas Rocío Montejano Rosa De Miguel Marta Montero-Alonso Oskar Ayerdi Cristina Hernández-Gutierrez Adriá Curran Jose R. Arribas Berta Rodés Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV Microorganisms HIV infection blood telomere length epigenetic age acceleration monocyte activation cardiovascular disease diabetes |
| title | Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV |
| title_full | Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV |
| title_fullStr | Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV |
| title_full_unstemmed | Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV |
| title_short | Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV |
| title_sort | monocyte activation and ageing biomarkers in the development of cardiovascular ischaemic events or diabetes in people with hiv |
| topic | HIV infection blood telomere length epigenetic age acceleration monocyte activation cardiovascular disease diabetes |
| url | https://www.mdpi.com/2076-2607/11/7/1818 |
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