Valproic acid-associated pancytopenia: A dose-dependent adverse effect
Pancytopenia (PCP) is a life-threatening condition which is rarely associated with valproic acid (VPA). We present a case of an adult female with epilepsy that was seizure-free for the last three years. She was in use of VPA 500 mg bid. The subject reported that she recently had new seizures. VPA do...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2019-09-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2019.3/RJN_2019_3_Art-09.pdf |
| _version_ | 1811203981407420416 |
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| author | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Juliana Oliveira Freitas Silveira |
| author_facet | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Juliana Oliveira Freitas Silveira |
| author_sort | Jamir Pitton Rissardo |
| collection | DOAJ |
| description | Pancytopenia (PCP) is a life-threatening condition which is rarely associated with valproic acid (VPA). We present a case of an adult female with epilepsy that was seizure-free for the last three years. She was in use of VPA 500 mg bid. The subject reported that she recently had new seizures. VPA dose was increased to 500mg tid. One-month later, she was asymptomatic and seizure-free. Laboratory tests showed PCP. VPA dose was decreased to 500mg bid and maintained. One-month later, the complete blood cell count was normal. After one-year, the patient reported new episodes of convulsion. VPA was increased to 500 mg tid. One-month later, the laboratory tests revealed PCP. Valproic acid was discontinued. Carbamazepine 200 mg tid was started. After two-months, the laboratory tests were normal. The subject was seizure-free and asymptomatic for the last year. |
| first_indexed | 2024-04-12T03:05:07Z |
| format | Article |
| id | doaj.art-9a2cdd796a42481983e5261f5ddc46ce |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-12T03:05:07Z |
| publishDate | 2019-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-9a2cdd796a42481983e5261f5ddc46ce2022-12-22T03:50:32ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942019-09-0118315015310.37897/RJN.2019.3.9Valproic acid-associated pancytopenia: A dose-dependent adverse effectJamir Pitton Rissardo0Ana Letícia Fornari Caprara1Juliana Oliveira Freitas Silveira2Neurology Department, Federal University of Santa Maria, RS, BrazilNeurology Department, Federal University of Santa Maria, RS, BrazilNeurology Department, Federal University of Santa Maria, RS, BrazilPancytopenia (PCP) is a life-threatening condition which is rarely associated with valproic acid (VPA). We present a case of an adult female with epilepsy that was seizure-free for the last three years. She was in use of VPA 500 mg bid. The subject reported that she recently had new seizures. VPA dose was increased to 500mg tid. One-month later, she was asymptomatic and seizure-free. Laboratory tests showed PCP. VPA dose was decreased to 500mg bid and maintained. One-month later, the complete blood cell count was normal. After one-year, the patient reported new episodes of convulsion. VPA was increased to 500 mg tid. One-month later, the laboratory tests revealed PCP. Valproic acid was discontinued. Carbamazepine 200 mg tid was started. After two-months, the laboratory tests were normal. The subject was seizure-free and asymptomatic for the last year.https://rjn.com.ro/articles/2019.3/RJN_2019_3_Art-09.pdfvalproic acidpancytopeniaepilepsy |
| spellingShingle | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Juliana Oliveira Freitas Silveira Valproic acid-associated pancytopenia: A dose-dependent adverse effect Romanian Journal of Neurology valproic acid pancytopenia epilepsy |
| title | Valproic acid-associated pancytopenia: A dose-dependent adverse effect |
| title_full | Valproic acid-associated pancytopenia: A dose-dependent adverse effect |
| title_fullStr | Valproic acid-associated pancytopenia: A dose-dependent adverse effect |
| title_full_unstemmed | Valproic acid-associated pancytopenia: A dose-dependent adverse effect |
| title_short | Valproic acid-associated pancytopenia: A dose-dependent adverse effect |
| title_sort | valproic acid associated pancytopenia a dose dependent adverse effect |
| topic | valproic acid pancytopenia epilepsy |
| url | https://rjn.com.ro/articles/2019.3/RJN_2019_3_Art-09.pdf |
| work_keys_str_mv | AT jamirpittonrissardo valproicacidassociatedpancytopeniaadosedependentadverseeffect AT analeticiafornaricaprara valproicacidassociatedpancytopeniaadosedependentadverseeffect AT julianaoliveirafreitassilveira valproicacidassociatedpancytopeniaadosedependentadverseeffect |