Factor VIIa Regulates the Level of Cell-Surface Tissue Factor through Separate but Cooperative Mechanisms

Factor VIIa Regulates the Level of Cell-Surface Tissue Factor through Separate but Cooperative Mechanisms

Procoagulant activity of tissue factor (TF) in response to injury or inflammation is accompanied with cellular signals which determine the fate of cells. However, to prevent excessive signalling, TF is rapidly dissipated through release into microvesicles, and/or endocytosis. To elucidate the mechan...

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Bibliographic Details
Main Authors: Yahya Madkhali, Araci M. R. Rondon, Sophie Featherby, Anthony Maraveyas, John Greenman, Camille Ettelaie
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
tissue factor
factor VIIa
protease-activated receptor-2
caveolae
cholesterol-rich microdomins
cell signalling
Online Access:https://www.mdpi.com/2072-6694/13/15/3718

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