Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa
The prevalence of pre-diabetes is increasing in rapidly urbanizing cities, especially in individuals aged 25 − 45 years old. Studies also indicate that this condition is associated with aberrant immune responses that are also influenced by environmental factors. This study sought to investigate chan...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Immunotoxicology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/1547691X.2023.2290282 |
| _version_ | 1826864861738434560 |
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| author | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi |
| author_facet | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi |
| author_sort | Nomusa Christina Mzimela |
| collection | DOAJ |
| description | The prevalence of pre-diabetes is increasing in rapidly urbanizing cities, especially in individuals aged 25 − 45 years old. Studies also indicate that this condition is associated with aberrant immune responses that are also influenced by environmental factors. This study sought to investigate changes in the concentration of immune cells and select inflammatory markers in patients with pre-diabetes in Durban, South Africa. Blood samples collected from King Edward Hospital, after obtaining ethics approval, were divided into non-diabetic (ND), pre-diabetic (PD) and type 2 diabetic (T2D) using ADA criteria. In each sample, the concentration of immune cells and select inflammatory markers were determined. The results showed a significant increase in eosinophil and basophil levels in the PD group as compared to the ND group. Compared to ND, the PD and T2D groups had significant increases in serum TNFα, CD40L and fibrinogen concentrations. Additionally, there were decreases in serum CRP, IL-6, and P-selectin in the PD group while these markers increased in the T2D group. These findings were indicative of immune activation and highlight the impact of pre-diabetes in this population. More studies are recommended with a higher number of samples that are stratified by gender and represent the gender ratio in the city. |
| first_indexed | 2024-03-08T23:09:39Z |
| format | Article |
| id | doaj.art-9a2fea273c4445f0a0ebdf623adf91b4 |
| institution | Directory Open Access Journal |
| issn | 1547-691X 1547-6901 |
| language | English |
| last_indexed | 2025-02-16T21:30:41Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Immunotoxicology |
| spelling | doaj.art-9a2fea273c4445f0a0ebdf623adf91b42025-01-17T12:52:14ZengTaylor & Francis GroupJournal of Immunotoxicology1547-691X1547-69012024-12-0121110.1080/1547691X.2023.2290282Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South AfricaNomusa Christina Mzimela0Aubrey Mbulelo Sosibo1Phikelelani Siphosethu Ngubane2Andile Khathi3School of Laboratory Medicine and Medical Science, College of Health SciencesSchool of Laboratory Medicine and Medical Science, College of Health SciencesSchool of Laboratory Medicine and Medical Science, College of Health SciencesSchool of Laboratory Medicine and Medical Science, College of Health SciencesThe prevalence of pre-diabetes is increasing in rapidly urbanizing cities, especially in individuals aged 25 − 45 years old. Studies also indicate that this condition is associated with aberrant immune responses that are also influenced by environmental factors. This study sought to investigate changes in the concentration of immune cells and select inflammatory markers in patients with pre-diabetes in Durban, South Africa. Blood samples collected from King Edward Hospital, after obtaining ethics approval, were divided into non-diabetic (ND), pre-diabetic (PD) and type 2 diabetic (T2D) using ADA criteria. In each sample, the concentration of immune cells and select inflammatory markers were determined. The results showed a significant increase in eosinophil and basophil levels in the PD group as compared to the ND group. Compared to ND, the PD and T2D groups had significant increases in serum TNFα, CD40L and fibrinogen concentrations. Additionally, there were decreases in serum CRP, IL-6, and P-selectin in the PD group while these markers increased in the T2D group. These findings were indicative of immune activation and highlight the impact of pre-diabetes in this population. More studies are recommended with a higher number of samples that are stratified by gender and represent the gender ratio in the city.https://www.tandfonline.com/doi/10.1080/1547691X.2023.2290282Immune cellsinflammatory markerspre-diabetesDurbanSouth Africa |
| spellingShingle | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa Journal of Immunotoxicology Immune cells inflammatory markers pre-diabetes Durban South Africa |
| title | Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa |
| title_full | Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa |
| title_fullStr | Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa |
| title_full_unstemmed | Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa |
| title_short | Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa |
| title_sort | investigation into changes in inflammatory and immune cell markers in pre diabetic patients from durban south africa |
| topic | Immune cells inflammatory markers pre-diabetes Durban South Africa |
| url | https://www.tandfonline.com/doi/10.1080/1547691X.2023.2290282 |
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