The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action
Nuclear hormone receptors (NRs) regulate transcription of the target genes in a ligand-dependent manner in either a positive or negative direction, depending on the case. Deacetylation of histone tails is associated with transcriptional repression. A nuclear receptor corepressor (N-CoR) and a silenc...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/17/9138 |
| _version_ | 1797521387288526848 |
|---|---|
| author | Sumiyasu Ishii |
| author_facet | Sumiyasu Ishii |
| author_sort | Sumiyasu Ishii |
| collection | DOAJ |
| description | Nuclear hormone receptors (NRs) regulate transcription of the target genes in a ligand-dependent manner in either a positive or negative direction, depending on the case. Deacetylation of histone tails is associated with transcriptional repression. A nuclear receptor corepressor (N-CoR) and a silencing mediator for retinoid and thyroid hormone receptors (SMRT) are the main corepressors responsible for gene suppression mediated by NRs. Among numerous histone deacetylases (HDACs), HDAC3 is the core component of the N-CoR/SMRT complex, and plays a central role in NR-dependent repression. Here, the roles of HDAC3 in ligand-independent repression, gene repression by orphan NRs, NRs antagonist action, ligand-induced repression, and the activation of a transcriptional coactivator are reviewed. In addition, some perspectives regarding the non-canonical mechanisms of HDAC3 action are discussed. |
| first_indexed | 2024-03-10T08:11:52Z |
| format | Article |
| id | doaj.art-9a332e35e53a4668819eb154bab39a83 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:11:52Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a332e35e53a4668819eb154bab39a832023-11-22T10:38:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217913810.3390/ijms22179138The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor ActionSumiyasu Ishii0Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8501, JapanNuclear hormone receptors (NRs) regulate transcription of the target genes in a ligand-dependent manner in either a positive or negative direction, depending on the case. Deacetylation of histone tails is associated with transcriptional repression. A nuclear receptor corepressor (N-CoR) and a silencing mediator for retinoid and thyroid hormone receptors (SMRT) are the main corepressors responsible for gene suppression mediated by NRs. Among numerous histone deacetylases (HDACs), HDAC3 is the core component of the N-CoR/SMRT complex, and plays a central role in NR-dependent repression. Here, the roles of HDAC3 in ligand-independent repression, gene repression by orphan NRs, NRs antagonist action, ligand-induced repression, and the activation of a transcriptional coactivator are reviewed. In addition, some perspectives regarding the non-canonical mechanisms of HDAC3 action are discussed.https://www.mdpi.com/1422-0067/22/17/9138histone deacetylase 3nuclear hormone receptornuclear receptor corepressorsilencing mediator for retinoid and thyroid hormone receptors |
| spellingShingle | Sumiyasu Ishii The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action International Journal of Molecular Sciences histone deacetylase 3 nuclear hormone receptor nuclear receptor corepressor silencing mediator for retinoid and thyroid hormone receptors |
| title | The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action |
| title_full | The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action |
| title_fullStr | The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action |
| title_full_unstemmed | The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action |
| title_short | The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action |
| title_sort | role of histone deacetylase 3 complex in nuclear hormone receptor action |
| topic | histone deacetylase 3 nuclear hormone receptor nuclear receptor corepressor silencing mediator for retinoid and thyroid hormone receptors |
| url | https://www.mdpi.com/1422-0067/22/17/9138 |
| work_keys_str_mv | AT sumiyasuishii theroleofhistonedeacetylase3complexinnuclearhormonereceptoraction AT sumiyasuishii roleofhistonedeacetylase3complexinnuclearhormonereceptoraction |